Bioaccessibility of different types of phenolic compounds co-encapsulated in alginate/chitosan-coated zein nanoparticles

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dc.contributor.authorCarrasco Sandoval, Jonathan
dc.contributor.authorAranda Bustos, Mario
dc.contributor.authorHenriquez Aedo, Karem
dc.contributor.authorLopez Rubio, Amparo
dc.contributor.authorFabra, Maria Jose
dc.date.accessioned2024-01-10T13:10:16Z
dc.date.available2024-01-10T13:10:16Z
dc.date.issued2021
dc.description.abstractSimultaneous administration of different phenolic compounds might produce a synergistic effect offering a greater activity against chronic non-communicable diseases. This has prompted significant interest in developing nanodelivery systems that simultaneously encapsulate different bioactives and protect them from gastrointestinal digestion. This work aimed at evaluating the suitability of zein (ZN) and zein/polysaccharide-based nanoparticles to co-encapsulate different types of phenolic compounds and understand how increasing the complexity of the nanoparticulate systems affected the bioaccessibility of the polyphenols. Two phenolic acids, two glycosylated flavonoids, and three flavonoid aglycones were successfully co-encapsulated in the three nanoparticulate systems. The encapsulation efficiency of phenolic compounds loaded on ZN ranged between 95.3 and 98.5%. The incorporation of the coating-layers (alginate - algZN- and chitosan -alg/chiZN-) significantly increased the encapsulation efficiency of phenolic acids and glycosylated flavonoids. The bioaccessibility of phenolic compounds loaded on ZN increased by at least 50.2%. Enhanced bioaccessibility of phenolic acids and glycosylated flavonoids was observed upon coating with alginate, while the greatest polyphenol bioaccessibility was seen for the alg/chiZN (over 65.8%). The greatest bioaccessibility was observed for polar phenolic acids, followed by glycosylated flavonoids. Therefore, the developed systems could be potentially useful to co-encapsulate different types of phenolic compounds and to improve their bioaccessibility.
dc.description.funderNational Fund for Scientific & Technological Development (FONDECYT)
dc.description.funderInternational Cooperation Program from National Agency of Research and Development (ANID)
dc.description.funderFund for Scientific and Technological Equipment (FONDEQUIP)
dc.fechaingreso.objetodigital01-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.lwt.2021.112024
dc.identifier.eissn1096-1127
dc.identifier.issn0023-6438
dc.identifier.urihttps://doi.org/10.1016/j.lwt.2021.112024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77821
dc.identifier.wosidWOS:000679281200007
dc.information.autorucFacultad de Química y de Farmacia; Aranda Bustos, Mario Antonio; S/I; 1103178
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherELSEVIER
dc.revistaLWT-FOOD SCIENCE AND TECHNOLOGY
dc.rightsacceso restringido
dc.subjectPhenolic compounds
dc.subjectZein
dc.subjectAlginate
dc.subjectChitosan
dc.subjectNanoparticles
dc.subjectPHYSICOCHEMICAL STABILITY
dc.subjectEPIGALLOCATECHIN GALLATE
dc.subjectBIOPOLYMER NANOPARTICLES
dc.subjectCONTROLLED-RELEASE
dc.subjectDRUG-DELIVERY
dc.subjectCURCUMIN
dc.subjectANTIOXIDANT
dc.subjectFOOD
dc.subjectRESVERATROL
dc.subjectFABRICATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBioaccessibility of different types of phenolic compounds co-encapsulated in alginate/chitosan-coated zein nanoparticles
dc.typeartículo
dc.volumen149
sipa.codpersvinculados1103178
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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