COLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION

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dc.contributor.authorVERGARA, C
dc.contributor.authorRAMIREZ, B
dc.contributor.authorBEHRENS, MI
dc.date.accessioned2025-01-23T19:21:40Z
dc.date.available2025-01-23T19:21:40Z
dc.date.issued1993
dc.description.abstractA low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle apamin receptors, determined by I-125-apamin binding to membrane fractions. The increase in apamin receptors was correlated with repetitive discharges resembling myotonic potentials in the electromyogram, that were blockable by apamin. Here we show that the increase in muscle apamin receptors and the alteration of the electromyogram are followed closely by a slowing of the twitch relaxation, that in turn, is decreased by apamin. Furthermore, the presence of myotonic-like alterations in the electromyogram and a slowing of muscle relaxation when muscle apamin receptors are increased suggests that these channels may participate, among other factors, in the generation of some kinds of myotonia. (C) 1993 John Wiley & Sons, Inc.
dc.description.funderNIGMS NIH HHS
dc.fuente.origenWOS
dc.identifier.issn0148-639X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98833
dc.identifier.wosidWOS:A1993LT92900007
dc.issue.numero9
dc.language.isoen
dc.pagina.final940
dc.pagina.inicio935
dc.revistaMuscle & nerve
dc.rightsacceso restringido
dc.subjectAPAMIN-RECEPTORS
dc.subjectCOLCHICINE
dc.subjectAXONAL FLOW
dc.subjectTWITCH RELAXATION
dc.subjectMYOTONIA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCOLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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