Differential expression of programmed cell death ligand 1 (PD-L1) and inflammatory cells in basal cell carcinoma subtypes

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dc.contributor.authorGompertz-Mattar, Matias
dc.contributor.authorPerales, Juan
dc.contributor.authorSahu, Aditi
dc.contributor.authorMondaca, Sebastian
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorUribe, Pablo
dc.contributor.authorNavarrete-Dechent, Cristian
dc.date.accessioned2025-01-20T22:01:43Z
dc.date.available2025-01-20T22:01:43Z
dc.date.issued2022
dc.description.abstractFew studies have evaluated programmed cell death ligand (PD-L1) expression and lymphocytic infiltrates in Basal Cell Carcinoma (BCC). The objectives of this study are to assess PD-L1 expression and markers of local immune response in nodular, superficial, and morpheaform BCC, and compare it to normal, sun-exposed skin from the periphery of intradermal nevi. This was a retrospective study that included three histological subtypes of BCCs, and sun-exposed skin from the periphery of dermal nevi as quality controls. Tissue microarrays (TMA) were constructed with subsequent staining of H&E and immunohistochemistry (IHC) for CD4, CD8, FOXP3 and PD-L1. Non-automated quantification of the infiltrate in the intratumoral and stromal compartments on TMAs was performed. A total of 115 BCC (39 nodular, 39 morpheaform, and 37 superficial) and 41 sun-exposed skin samples were included (mean age 65.4 years; 52.6% females). BCC showed higher expression of PD-L1 (5.4 vs 0.7%, p < 0.001), CD8 (29.8 vs 19.7%, p = 0.002), and FOXP3 (0.3 vs 0.06%, p = 0.022) compared to sun-exposed skin. There was a higher PD-L1 expression in nodular BCC compared with other subtypes. Low-risk BCC subtypes (superficial and nodular) exhibited more PD-L1 expression in intratumoral and stromal immune infiltrates as compared to high-risk BCC subtypes. As a limitation, no immune cells function was evaluated in this study, only the presence/absence of T-lymphocyte sub-populations was recorded. Substantial differences in both PD-L1 expression and lymphocytic infiltrates were found amongst the histological subtypes of BCC and sun-exposed skin. Highest PD-L1 expression was found in nodular BCCs which suggests a potentially targetable strategy in the treatment of this most common BCC subtype.
dc.description.funderDepartment of Dermatology internal research funds
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00403-021-02289-w
dc.identifier.eissn1432-069X
dc.identifier.issn0340-3696
dc.identifier.urihttps://doi.org/10.1007/s00403-021-02289-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93875
dc.identifier.wosidWOS:000706942400001
dc.issue.numero8
dc.language.isoen
dc.pagina.final786
dc.pagina.inicio777
dc.revistaArchives of dermatological research
dc.rightsacceso restringido
dc.subjectBasal cell carcinoma
dc.subjectProgrammed cell death ligand 1
dc.subjectPD-1
dc.subjectPD-L1
dc.subjectLymphocytes
dc.subjectImmunotherapy
dc.subjectImmunohistochemistry
dc.subjectStains
dc.subjectDiagnosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential expression of programmed cell death ligand 1 (PD-L1) and inflammatory cells in basal cell carcinoma subtypes
dc.typeartículo
dc.volumen314
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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