NEURAL 16S ACETYLCHOLINESTERASE IS SOLUBILIZED BY HEPARIN
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1983
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Abstract
The effect of heparin, a sulfated glycosaminoglycan, on the solubilization of rat sciatic-nerve acetylcholinesterase (acetylcholine acetylhydrolase; AChE; EC 3.1.1.7) was studied. Heparin solubilized esterase activity from ligated nerves. Sedimentation analysis revealed this activity to be mainly the 16S form. Chondroitin sulfate did not solubilize AChE activity, and protamine eliminated the solubilizng effect. The results suggest the involvement of sulfated glycosaminoglycans in the intra-axonal localization and transport of 16S AChE.