Dopamine modulates carotid nerve responses induced by acetylcholine on the cat petrosal ganglion in vitro

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dc.contributor.authorAlcayaga, J
dc.contributor.authorVaras, R
dc.contributor.authorArroyo, J
dc.contributor.authorIturriaga, R
dc.contributor.authorZapata, P
dc.date.accessioned2025-01-21T01:32:02Z
dc.date.available2025-01-21T01:32:02Z
dc.date.issued1999
dc.description.abstractWe have recently reponed that application of acetylcholine (ACh) or nicotine to the petrosal ganglion-the sensory ganglion of the glossopharyngeal nerve-elicits a burst of discharges in the carotid nerve branch, innervating the carotid body and sinus, but not in the glossopharyngeal branch, innervating the tongue and pharynx, Thus, the perikarya of sensory neurons for the carotid bifurcation exhibit selective cholinosensitivity. Since dopamine (DA) modulates carotid nerve chemosensory activity, we searched for the presence of DA sensitivity at the perikarya of these neurons in the cat petrosal ganglion superfused in vitro. Applications of DA in doses of up to 5 mg to the ganglion did not modify the rate of spontaneous discharges in the carotid nerve, However, if DA was applied 30 s before ACh injections, ACh-evoked reactions were modified: low doses of DA enhanced the subsequent responses to ACh, while high doses of DA depressed the responses to ACh. This depressant effect of DA on ACh responses was partially antagonized by adding spiroperone to the superfusate. Our results show that the response to ACh of petrosal ganglion neurons projecting through the carotid nerve is modulated by DA acting on D-2 receptors located in the somata of these neurons. Thus, dopaminergic modulation of cholinosensitivity could be shared also by the membranes of peripheral endings and perikarya of primary sensory neurons involved in arterial chemoreception. (C) 1999 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97190
dc.identifier.wosidWOS:000080939700010
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final103
dc.pagina.inicio97
dc.revistaBrain research
dc.rightsacceso restringido
dc.subjectacetylcholine
dc.subjectarterial chemoreceptor
dc.subjectcarotid body
dc.subjectdopamine
dc.subjectpetrosal ganglion
dc.subjectsensory ganglion
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDopamine modulates carotid nerve responses induced by acetylcholine on the cat petrosal ganglion in vitro
dc.typeartículo
dc.volumen831
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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