Disparities in metabolic dysfunction-associated steatotic liver disease and cardiometabolic conditions in low and lower middle-income countries: a systematic analysis from the global burden of disease study 2019

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dc.contributor.authorDanpanichkul, Pojsakorn
dc.contributor.authorSuparan, Kanokphong
dc.contributor.authorDutta, Priyata
dc.contributor.authorKaeosri, Chuthathip
dc.contributor.authorSukphutanan, Banthoon
dc.contributor.authorPang, Yanfang
dc.contributor.authorKulthamrongsri, Narathorn
dc.contributor.authorJaisa-aad, Methasit
dc.contributor.authorNg, Cheng Han
dc.contributor.authorTeng, Margaret
dc.contributor.authorNakano, Masahito
dc.contributor.authorMorishita, Asahiro
dc.contributor.authorAlkhouri, Naim
dc.contributor.authorYang, Ju Dong
dc.contributor.authorChen, Vincent L.
dc.contributor.authorKim, Donghee
dc.contributor.authorFallon, Michael B.
dc.contributor.authorDiaz, Luis Antonio
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorMantzoros, Christos S.
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorLazarus, Jeffrey, V
dc.contributor.authorWijarnpreecha, Karn
dc.date.accessioned2025-01-20T16:13:24Z
dc.date.available2025-01-20T16:13:24Z
dc.date.issued2024
dc.description.abstractObjective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiometabolic conditions affect populations across economic strata. Nevertheless, there are limited epidemiological studies addressing these diseases in low (LICs) and lower-middle-income countries (lower MICs). Therefore, an analysis of the trend of MASLD and cardiometabolic conditions in these countries is necessary. Methods: From 2000 to 2019, jointpoint regression analysis was employed to calculate the prevalence, mortality, and disability-adjusted life years (DALYs) for cardiometabolic conditions including MASLD, type 2 diabetes mellitus (T2DM), dyslipidemia (DLP), hypertension (HTN), obesity, peripheral artery disease (PAD), atrial fibrillation and flutter (AF/AFL), ischemic heart disease (IHD), stroke, and chronic kidney disease from HTN and T2DM, in LICs and lower MICs (according to the World Bank Classification 2019) using the Global Burden of Disease 2019 data. Results: Among the eleven cardiometabolic conditions, MASLD (533.65 million), T2DM (162.96 million), and IHD (76.81 million) had the highest prevalence in LICs and Lower MICs in 2019. MASLD represented the largest proportion of global prevalence in these countries (43 %). From 2000 to 2019, mortality in LICs and lower MICs increased in all cardiometabolic conditions, with obesity-related mortality having the highest increase ( +134 %). During this timeframe, there were increased age-standardized death rates (ASDR) from obesity, PAD, and AF/ AFL. From all conditions, the DALYs-to-prevalence ratio was higher in LICs and lower MICs than the global average. Conclusion: The burden of MASLD and cardiometabolic conditions is increasing worldwide, with LICs and lower MICs experiencing higher (DALYs) disability per prevalence. As these conditions are preventable, counteracting these trends requires not only the modification of ongoing actions but also the strategizing of immediate interventions.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.metabol.2024.155958
dc.identifier.eissn1532-8600
dc.identifier.issn0026-0495
dc.identifier.urihttps://doi.org/10.1016/j.metabol.2024.155958
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90385
dc.identifier.wosidWOS:001267008300001
dc.language.isoen
dc.revistaMetabolism-clinical and experimental
dc.rightsacceso restringido
dc.subjectEpidemiology
dc.subjectLiver disease
dc.subjectMetabolic syndrome
dc.subjectDisparity
dc.subjectMASLD
dc.subjectNAFLD
dc.subjectNon-alcoholic fatty liver disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDisparities in metabolic dysfunction-associated steatotic liver disease and cardiometabolic conditions in low and lower middle-income countries: a systematic analysis from the global burden of disease study 2019
dc.typeartículo
dc.volumen158
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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