Smoking molecular damage in bronchial epithelium

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dc.contributor.authorWistuba, II
dc.contributor.authorMao, L
dc.contributor.authorGazdar, AF
dc.date.accessioned2025-01-21T01:10:27Z
dc.date.available2025-01-21T01:10:27Z
dc.date.issued2002
dc.description.abstractOur understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.
dc.fuente.origenWOS
dc.identifier.doi10.1038/sj.onc.1205806
dc.identifier.issn0950-9232
dc.identifier.urihttps://doi.org/10.1038/sj.onc.1205806
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96686
dc.identifier.wosidWOS:000178618000004
dc.issue.numero48
dc.language.isoen
dc.pagina.final7306
dc.pagina.inicio7298
dc.revistaOncogene
dc.rightsacceso restringido
dc.subjectsmoking
dc.subjectpreneoplasia
dc.subjectlung cancer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSmoking molecular damage in bronchial epithelium
dc.typeartículo
dc.volumen21
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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