Serum proteomic patterns for detection of prostate cancer

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dc.contributor.authorPetricoin, EF
dc.contributor.authorOrnstein, DK
dc.contributor.authorPaweletz, CP
dc.contributor.authorArdekani, A
dc.contributor.authorHackett, PS
dc.contributor.authorHitt, BA
dc.contributor.authorVelassco, A
dc.contributor.authorTrucco, C
dc.contributor.authorWiegand, L
dc.contributor.authorWood, K
dc.contributor.authorSimone, CB
dc.contributor.authorLevine, PJ
dc.contributor.authorLinehan, WM
dc.contributor.authorEmmert Buck, MR
dc.contributor.authorSteinberg, SM
dc.contributor.authorKohn, EC
dc.contributor.authorLiotta, LA
dc.date.accessioned2024-01-10T12:08:31Z
dc.date.available2024-01-10T12:08:31Z
dc.date.issued2002
dc.description.abstractPathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal the most fit pattern that discriminated the training set of sera of men with a histopathologic diagnosis of prostate cancer (serum prostate-specific antigen [PSA] greater than or equal to 4 ng/mL) from those men without prostate cancer (serum PSA level < 1 ng/mL). Mass spectra of blinded sera (N = 266) from a test set derived from men with prostate cancer or men without prostate cancer were matched against the discriminating pattern revealed by the training set. A predicted diagnosis of benign disease or cancer was rendered based on similarity to the discriminating pattern discovered from the training set. The proteomic pattern correctly predicted 36 (95%, 95% confidence interval [CI] = 82% to 99%) of 38 patients with prostate cancer, while 177 (78%, 95% CI = 72% to 83%) of 228 patients were correctly classified as having benign conditions. For men with marginally elevated PSA levels (4-10 ng/mL; n = 137), the specificity was 71%. If validated in future series, serum proteomic pattern diagnostics may be of value in deciding whether to perform a biopsy on a man with an elevated PSA level.
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.issn0027-8874
dc.identifier.pubmedidMEDLINE:12381711
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76400
dc.identifier.wosidWOS:000178562900013
dc.information.autorucMedicina;Velasco A;S/I;58191
dc.issue.numero20
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1578
dc.pagina.inicio1576
dc.publisherOXFORD UNIV PRESS INC
dc.revistaJOURNAL OF THE NATIONAL CANCER INSTITUTE
dc.rightsregistro bibliográfico
dc.subjectPROTEIN BIOCHIP
dc.subjectANTIGEN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSerum proteomic patterns for detection of prostate cancer
dc.typeartículo
dc.volumen94
sipa.codpersvinculados58191
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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