ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

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dc.contributor.authorAndrea Ibacache, Juana
dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorArancibia, Veronica
dc.contributor.authorTheoduloz, Cristina
dc.contributor.authorMuccioli, Giulio G.
dc.contributor.authorBenites, Julio
dc.date.accessioned2025-01-23T21:27:30Z
dc.date.available2025-01-23T21:27:30Z
dc.date.issued2016
dc.description.abstractA variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 mu M. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line.
dc.fuente.origenWOS
dc.identifier.issn0717-9707
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101383
dc.identifier.wosidWOS:000393079900008
dc.issue.numero4
dc.language.isoen
dc.pagina.final3194
dc.pagina.inicio3191
dc.revistaJournal of the chilean chemical society
dc.rightsacceso restringido
dc.subjectIsoquinolinequinones
dc.subjecthalf-wave potentials
dc.subjectMTT assay
dc.subjectantiproliferative activity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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