Gap junctions in the control of vascular function

Simple item page
dc.contributor.authorFigueroa, Xavier
dc.date.accessioned2017-04-11T14:43:37Z
dc.date.available2017-04-11T14:43:37Z
dc.date.issued2009
dc.description.abstractDirect intercellular communication via gap junctions is critical in the control and coordination of vascular function. In the cardiovascular system, gap junctions are made up of one or more of four connexin proteins: Cx37, Cx40, Cx43, and Cx45. The expression of more than one gap-junction protein in the vasculature is not redundant. Rather, vascular connexins work in concert, first during the development of the cardiovascular system, and then in integrating smooth muscle and endothelial cell function, and in coordinating cell function along the length of the vessel wall. In addition, connexin-based channels have emerged as an important signaling pathway in the astrocyte-mediated neurovascular coupling. Direct electrical communication between endothelial cells and vascular smooth muscle cells via gap junctions is thought to play a relevant role in the control of vasomotor tone, providing the signaling pathway known as endothelium-derived hyperpolarizing factor (EDHF). Consistent with the importance of gap junctions in the regulation of vasomotor tone and arterial blood pressure, the expression of connexins is altered in diseases associated with vascular complications. In this review, we discuss the participation of connexin-based channels in the control of vascular function in physiologic and pathologic conditions, with a special emphasis on hypertension and diabetes.
dc.format.extent15 páginas
dc.identifier.doi10.1089/ars.2008.2117
dc.identifier.issn1523-0864
dc.identifier.urihttps://doi.org/10.1089/ars.2008.2117
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/18635
dc.identifier.wosidWOS:000261863200007
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final266
dc.pagina.inicio[251]
dc.revistaAntioxid Redox Signales_ES
dc.rightsacceso restringido
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherDiabetes mellitus - Patologíaes_ES
dc.subject.otherUniones Gapes_ES
dc.subject.otherHipertensiónes_ES
dc.titleGap junctions in the control of vascular functiones_ES
dc.typeartículo
dc.volumen11
sipa.codpersvinculados1437
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gap Junctions in the Control of Vascular Function.pdf
Size:
6.99 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas