Biocompatibility in hemodialysis: artificial membrane and human blood interactions

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dc.article.number482
dc.catalogadorpva
dc.contributor.authorÁvila Jiménez, Eduardo Rodolfo
dc.contributor.authorSepúlveda Palamara, Rodrigo Andrés
dc.contributor.authorRetamal Montes, Jaime Alejandro
dc.contributor.authorHachim Díaz, Daniel Jordi
dc.date.accessioned2025-08-25T21:50:12Z
dc.date.available2025-08-25T21:50:12Z
dc.date.issued2025
dc.date.updated2025-08-24T00:03:47Z
dc.description.abstractHemodialysis, a cornerstone therapy for chronic kidney disease, represented a crucial advance in the evolution of artificial organs. While its success is largely due to its efficiency in removing uremic toxins, an equally important challenge is to uphold the primum non nocere principle by minimizing the harmful effects of membrane–blood interactions. This review examines the complex mechanisms and key interactions underlying membrane biocompatibility, including complement activation, inflammation, and coagulation disturbances, paving the way for their clinical implications. We also summarize recent innovations in membrane materials and surface engineering aimed at improving hemocompatibility and promoting safer hemodialysis treatments for improved clinical outcomes. Highlights Membrane biocompatibility is essential for safe and effective hemodialysis, while bioincompatibility can trigger complement activation, inflammation, and coagulation disorders. Synthetic membranes generally demonstrate superior hemocompatibility compared with cellulose-based membranes. Adverse immune and inflammatory responses to membrane–blood interactions may contribute to oxidative stress, endothelial dysfunction, and immune exhaustion, impacting patient prognosis. Advances in membrane design and surface engineering offer promising strategies to improve safety and clinical outcomes.
dc.description.funderANID/FONDECYT; Folio: 11240633
dc.description.funderANID/Beca Doctorado Nacional; Folio: ANID N°21231166
dc.description.funderANID/FONDECYT; Folio: Regular 1241897
dc.fechaingreso.objetodigital2025-08-24
dc.format.extent32 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Nephrology. 2025 Aug 22;26(1):482
dc.identifier.doi10.1186/s12882-025-04401-y
dc.identifier.issn1471-2369
dc.identifier.urihttps://doi.org/10.1186/s12882-025-04401-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105271
dc.information.autorucEscuela de Medicina; Ávila Jiménez, Eduardo Rodolfo; S/I; 208077
dc.information.autorucEscuela de Medicina; Sepúlveda Palamara, Rodrigo Andrés; 0000-0002-9618-3686; 252768
dc.information.autorucEscuela de Medicina; Retamal Montes, Jaime Alejandro; 0000-0002-6817-3659; 175147
dc.information.autorucEscuela de Química; Hachim Díaz, Daniel Jordi; S/I; 149408
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherSpringer Nature
dc.revistaBMC Nephrology
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChronic kidney disease
dc.subjectBiocompatible materials
dc.subjectHemodialysis
dc.subjectArtificial membranes
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBiocompatibility in hemodialysis: artificial membrane and human blood interactions
dc.typeartículo
dc.volumen26
sipa.codpersvinculados208077
sipa.codpersvinculados252768
sipa.codpersvinculados175147
sipa.codpersvinculados149408
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