<i>Hox</i> genes control homocercal caudal fin development and evolution

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dc.contributor.authorCumplido, Nicolas
dc.contributor.authorArratia, Gloria
dc.contributor.authorDesvignes, Thomas
dc.contributor.authorMunoz-Sanchez, Salome
dc.contributor.authorPostlethwait, John H.
dc.contributor.authorAllende, Miguel L.
dc.date.accessioned2025-01-20T17:07:48Z
dc.date.available2025-01-20T17:07:48Z
dc.date.issued2024
dc.description.abstractAncient bony fishes had heterocercal tails, like modern sharks and sturgeons, with asymmetric caudal fins and a vertebral column extending into an elongated upper lobe. Teleost fishes, in contrast, developed a homocercal tail characterized by two separate equal-sized fin lobes and the body axis not extending into the caudal fin. A similar heterocercal-to-homocercal transition occurs during teleost ontogeny, although the underlying genetic and developmental mechanisms for either transition remain unresolved. Here, we investigated the role of hox13 genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish hox13 paralogs and phenotypes of CRISPR/Cas9-induced mutants showed that double hoxb13a and hoxc13a mutants fail to form a caudal fin. Furthermore, single mutants display heterocercal-like morphologies not seen since Mesozoic fossil teleosteomorphs. Relaxation of functional constraints after the teleost genome duplication may have allowed hox13 duplicates to neo- or subfunctionalize, ultimately contributing to the evolution of a homocercal tail in teleost fishes.
dc.fuente.origenWOS
dc.identifier.doi10.1126/sciadv.adj5991
dc.identifier.issn2375-2548
dc.identifier.urihttps://doi.org/10.1126/sciadv.adj5991
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90895
dc.identifier.wosidWOS:001188370500019
dc.issue.numero3
dc.language.isoen
dc.revistaScience advances
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>Hox</i> genes control homocercal caudal fin development and evolution
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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