Bioconjugates of toluidine blue derivatives with human serum albumin and their complexes with cucurbit[7]uril as drug delivery vehicles for photodynamic therapy

Simple item page
dc.catalogadordfo
dc.contributor.authorMariño Ocampo, Nory Johana
dc.contributor.authorDuggon, José Robinson
dc.contributor.authorZúñiga Nuñez, Daniel
dc.contributor.authorDaniel Guerra Díaz
dc.contributor.authorHeyne, Belinda
dc.contributor.authorFuentealba Patino, Denis Alberto
dc.date.accessioned2025-11-10T14:43:19Z
dc.date.available2025-11-10T14:43:19Z
dc.date.issued2025
dc.description.abstractPhotodynamic therapy (PDT) is a promising cancer treatment. The present work used two toluidine blue O (TBO) derivatives covalently conjugated to human serum albumin (HSA) as a drug delivery system and bound to cucurbit[7]uril (CB[7]) as a protective nanocapsule in order to study their effect of cellular uptake and phototoxicity in HeLa cells. This study explored covalent and noncovalent interactions with the delivery systems, including HSA-PS@CB[7] complexes, to optimize PDT efficacy. Supramolecular complexes between TBO derivatives and CB[7] exhibited high binding affinities, significantly improving the photophysical properties of the photosensitizers. In vitro studies in cancer cells demonstrated that HSA covalently bound to TBO derivatives led to significant increases in cellular uptake and was strongly influenced by the type of conjugation (disulfide bond versus thia-Michael adduct). The results suggest that combining the properties of HSA as a carrier and CB[7] as a protective nanocapsule could be exploited for improved PDT applications.
dc.fechaingreso.objetodigital2025-11-10
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1021/acsomega.5c03731
dc.identifier.urihttps://doi.org/10.1021/acsomega.5c03731
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/106711
dc.information.autorucEscuela de Química; Mariño Ocampo Nory Johana; 0000-0003-2013-9790; 1059618
dc.information.autorucESCUELA QUÍMICA Y FARMACIA; Zúñiga Nuñez Daniel; S/I; 240032
dc.information.autorucEscuela de Química; Fuentealba Patino Denis Alberto; 0000-0003-4798-7204; 160255
dc.language.isoes
dc.nota.accesoContenido completo
dc.revistaAcs omega
dc.rightsAcceso abierto
dc.rights.licenseAtribución/Reconocimiento 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleBioconjugates of toluidine blue derivatives with human serum albumin and their complexes with cucurbit[7]uril as drug delivery vehicles for photodynamic therapy
dc.typeartículo
sipa.codpersvinculados1059618
sipa.codpersvinculados240032
sipa.codpersvinculados160255
sipa.trazabilidadORCID;2025-11-03
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
bioconjugates-of-toluidine-blue-derivatives-with-human-serum-albumin-and-their-complexes-with-cucurbit-7-uril-as-drug.pdf
Size:
4.03 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas