Intracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity

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dc.contributor.authorPehlivanoglu B.
dc.contributor.authorBalci S.
dc.contributor.authorMemis B.
dc.contributor.authorDursun N.
dc.contributor.authorSaka B.
dc.contributor.authorReid M.D.
dc.contributor.authorBasturk O.
dc.contributor.authorBagci P.
dc.contributor.authorErbarut Seven I.
dc.contributor.authorJang K.T.
dc.contributor.authorOhike N.
dc.contributor.authorTajiri T.
dc.contributor.authorRoa J.C.
dc.contributor.authorSarmiento J.M.
dc.contributor.authorAdsay V.
dc.contributor.authorAdsay V.
dc.date.accessioned2025-05-01T10:30:14Z
dc.date.available2025-05-01T10:30:14Z
dc.date.issued2021
dc.description.abstract© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.Preinvasive tumor-forming gallbladder neoplasms that are composed of small, non-mucinous tubules with complex architecture remain a poorly characterized group. Here, we evaluated the clinicopathological characteristics of this entity. Twenty-eight examples were analyzed. Tumors were invariably pedunculated polyps with thin stalks, often presented as loosely attached intraluminal nodules, with cauliflower architecture (akin to cholesterol polyps) comprised of compact, back-to-back acinar-like, small tubular units with minimal/no cytoplasm showing variable complexity, creating a picture distinct from the other tubular type dysplasia in the gallbladder. Their limited stroma showed distinctive amorphous amyloid-like hyalinization (39%). While some had round nuclei with single prominent nucleoli, others exhibited slightly more elongated nuclei with washed out chromatin reminiscent of papillary thyroid carcinoma. Squamoid/meningothelial-like morules (71%) and subtle neuroendocrine cell clusters (39%) were frequent. The level of cytoarchitectural atypia qualified as high-grade dysplasia (HGD) in all cases, but none were invasive. The background mucosa showed no dysplasia, but cholesterolosis. The majority (n = 8/12) showed diffuse MUC6 expression and lacked MUC5AC expression. Based on these observations, 635 gallbladder carcinomas were re-analyzed for residual/adjacent lesions with entity-defining characteristics disclosed here, and none could be identified. Preinvasive tubular non-mucinous neoplasm of the gallbladder, which we propose to classify as intracholecystic tubular non-mucinous neoplasm, is a clinicopathologically discrete entity, which tends to occur in uninjured gallbladders and in association with cholesterol polyps. By being tubular, non-mucinous and MUC6-positive, it is akin to intraductal tubulopapillary neoplasms of pancreatobiliary tract, but it is also different in many other aspects. Although their cytoarchitectural complexity warrants an HGD/carcinoma classification, they do not show invasion and their distinct characteristics warrant their separate classification.
dc.description.funderANID
dc.description.funderSergio San Mart?n
dc.description.funderFONDECYT
dc.format.extent10 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1007/s00428-020-02877-7
dc.identifier.eissn14322307
dc.identifier.issn14322307 09456317
dc.identifier.pubmedid32691142
dc.identifier.scieloidS0716-27902024000100135
dc.identifier.scopusidSCOPUS_ID:85088267213
dc.identifier.urihttps://doi.org/10.1007/s00428-020-02877-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103604
dc.identifier.wosidWOS:000643656100016
dc.information.autorucEscuela de Medicina; Roa Strauch Juan Carlos Enrique; 0000-0001-8313-8774; 84743
dc.issue.numero105479
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final447
dc.pagina.inicio435
dc.relation.ispartof16th International Vasculitis & ANCA Workshop
dc.revistaVirchows Archiv
dc.rightsAcceso cerrado
dc.subjectAdenoma
dc.subjectGallbladder
dc.subjectPreinvasive neoplasm
dc.subjectPyloric
dc.subjectTubular Papillary
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleIntracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity
dc.typeartículo
dc.volumen478
sipa.codpersvinculados84743
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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