M2-polarized macrophages prevent preterm birth and improve neonatal survival and immunity

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dc.catalogadorvzp
dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorLiu, Zhenjie
dc.contributor.authorRomero, Roberto
dc.contributor.authorXu, Yi
dc.contributor.authorMiller, Derek
dc.contributor.authorGalaz Alarcón, José Carlo
dc.contributor.authorWinters, Andrew
dc.contributor.authorFarías Jofre, Marcelo Enrique
dc.contributor.authorTheis, Kevin
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-05-16T17:59:06Z
dc.date.available2025-05-16T17:59:06Z
dc.date.issued2024
dc.description.abstractPreterm birth (PTB), commonly preceded by preterm labor, is the leading cause of neonatal morbidity and mortality worldwide. Most cases of preterm labor are associated with sterile intra-amniotic inflammation (SIAI), an inflammatory condition without detectable microorganisms. To date, no successful strategies to treat SIAI have been developed. Herein, we present mechanistic proof that treatment with M2-polarized macrophages (M2 MΦ) can effectively prevent PTB [(HMGB1, n = 28 vs. HMGB1+M2 MΦ, n = 29) (p<0.05)] and neonatal mortality [(HMGB1, n = 20 litters vs. HMGB1+M2 MΦ, n = 14 litters) (p<0.001)] induced by the ultrasound-guided intra-amniotic injection of the alarmin HMGB1 in mice. M2 MΦ halt the premature pathway of labor by infiltrating maternal and fetal compartments, where they inhibit NLRP3 inflammasome activation triggered by HMGB1. Furthermore, M2 MΦ dampen the HMGB1-induced inflammatory response in the amniotic cavity and fetal lung. Notably, neonates exposed to HMGB1 in utero display a reduced capacity to clear bacterial infection and gut microbiome dysbiosis, which are restored by M2 MΦ treatment [(HMGB1, n = 10 vs. HMGB1+ M2 MΦ, n = 10) (p<0.001 and p<0.01, respectively)]. Our findings provide cogent evidence that M2 MΦ can serve as a cellular strategy to mitigate PTB and decrease neonatal mortality.
dc.format.extent2 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4049/jimmunol.212.supp.0355.5259
dc.identifier.eissn1550-6606
dc.identifier.issn0022-1767
dc.identifier.urihttps://doi.org/10.4049/jimmunol.212.supp.0355.5259
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104344
dc.identifier.wosidWOS:001408042000035
dc.information.autorucEscuela de Medicina; Galaz Alarcón, José Carlo; S/I; 1034327
dc.information.autorucEscuela de Medicina; Farías Jofre, Marcelo Enrique; 0000-0003-0473-2295; 12286
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.revistaJOURNAL OF IMMUNOLOGY
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleM2-polarized macrophages prevent preterm birth and improve neonatal survival and immunity
dc.typeartículo
dc.volumen212
sipa.codpersvinculados1034327
sipa.codpersvinculados12286
sipa.trazabilidadWOS;2025-02-08
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