Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

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dc.contributor.authorPadilla, Oslando
dc.contributor.authorSolís, Luisa.
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorAguayo González, Francisco
dc.contributor.authorKhan, Noureen.
dc.contributor.authorKoriyama, Chihaya.
dc.contributor.authorGonzález, Carolina
dc.contributor.authorAmpuero, Sandra.
dc.contributor.authorEizuru, Yoshito.
dc.contributor.authorAkiba, Suminori.
dc.date.accessioned2019-10-17T15:45:12Z
dc.date.available2019-10-17T15:45:12Z
dc.date.issued2011
dc.date.updated2019-10-14T18:51:27Z
dc.description.abstractAbstract Background Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.Abstract Background Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.
dc.fuente.origenBiomed Central
dc.identifier.citationInfectious Agents and Cancer. 2011 Jun 23;6(1):7
dc.identifier.doi10.1186/1750-9378-6-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26792
dc.identifier.wosidWOS:000208796300007
dc.issue.numeroNo. 7
dc.language.isoen
dc.pagina.final7
dc.pagina.inicio1
dc.revistaInfectious Agents and Canceres_ES
dc.rightsacceso abierto
dc.rights.holderAguayo et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.ods05 Gender equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.subject.otherVirus del Papilomaes_ES
dc.subject.othervirus de Epstein-BarrInfecciones bacterianases_ES
dc.subject.otherCáncer de mamaes_ES
dc.titleHuman papillomavirus and Epstein-Barr virus infections in breast cancer from chilees_ES
dc.typeartículo
dc.volumenVol. 6
sipa.codpersvinculados102063
sipa.codpersvinculados63885
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