Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

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dc.contributor.authorGodoy, B.
dc.contributor.authorMurgas, P.
dc.contributor.authorTichauer, J.
dc.contributor.authorVon Bernhardi, R.
dc.date.accessioned2025-01-20T23:56:45Z
dc.date.available2025-01-20T23:56:45Z
dc.date.issued2012
dc.description.abstractClass-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-kappa B signaling and increased production of IL1 beta and nitric oxide (NO). IL1 beta classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFN gamma-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation. (C) 2012 Elsevier B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jneuroim.2012.06.004
dc.identifier.issn0165-5728
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2012.06.004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95174
dc.identifier.wosidWOS:000309314700002
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final13
dc.pagina.inicio6
dc.revistaJournal of neuroimmunology
dc.rightsacceso restringido
dc.subjectGlia
dc.subjectIL1 beta
dc.subjectMAPK
dc.subjectNeuroinflammation
dc.subjectNF kappa B
dc.subjectSR-A
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleScavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture
dc.typeartículo
dc.volumen251
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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