Remifentanil requirements during propofol administration to block the somatic response to skin incision in children and adults

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dc.catalogadoraba
dc.contributor.authorMuñoz Letelier, Hernán Rodrigo
dc.contributor.authorCortínez Fernández, Luis Ignacio
dc.contributor.authorIbacache Figueroa, Mauricio Enrique
dc.contributor.authorAltermatt Couratier, Fernando René
dc.date.accessioned2024-08-23T19:46:17Z
dc.date.available2024-08-23T19:46:17Z
dc.date.issued2007
dc.description.abstractBACKGROUND: During sevoflurane administration, children require a remifentanil infusion rate twofold higher than adults to block responses to skin incision. Similar data concerning remifentanil requirements are unavailable during total IV anesthesia.", "METHODS: We prospectively determined the infusion rate (IR) of remifentanil necessary to block the somatic response to skin incision in 50% (IR50) of adults (n = 20, aged 20-60 yr) and children (n = 20, aged 3-11 yr) during propofol anesthesia., In each patient undergoing lower abdominal surgery, a remifentanil infusion was initiated, followed by target-controlled infusion of propofol set at a plasma concentration of 6 mu g/mL. After tracheal intubation, propofol was reduced to 3 mu g/mL, until the end of the study. Remifentanil IR was determined according to Dixon's up-and-down method, with the first patient in each group receiving 0.2 mu g (.) kg(-1) (.) min(-1) followed by the consecutive patient receiving 0.02 mu g (.) kg(-1) (.) min(-1) modifications according to the response of the previous patient. The remifentanil IR was kept unchanged for at least 20 min before surgery. At the beginning of surgery, only the skin incision was performed, and the somatic response was observed. If there was any gross movement of extremity the response was considered positive.", "RESULTS: The IR50 (CI95%) was 0.08 (0.06-0.12) mu g (.) kg(-1) (.) min(-1) in adults and 0.15 (0.13-0.17) mu g (.) kg(-1) (.) min(-1) in children (P < 0.001).", "CONCLUSION: These results demonstrate that, similar to sevoflurane anesthesia, during total IV anesthesia with propofol, children require a remifentanil IR almost twofold higher than adults to block the somatic response to skin incision.
dc.fuente.origenHistorial Académico
dc.fuente.origenORCID
dc.identifier.doi10.1213/01.ane.0000251201.81210.e7
dc.identifier.eissn526-7598
dc.identifier.issn0003-2999
dc.identifier.urihttps://doi.org/10.1213/01.ane.0000251201.81210.e7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87654
dc.identifier.wosidWOS:000243040100016
dc.information.autorucEscuela de Medicina; Muñoz Letelier, Hernán Rodrigo; S/I; 73573
dc.information.autorucEscuela de Medicina; Cortínez Fernández, Luis Ignacio; 0000-0001-8544-8768; 79356
dc.information.autorucEscuela de Medicina; Ibacache Figueroa, Mauricio Enrique; S/I; 817
dc.information.autorucEscuela de Medicina; Altermatt Couratier, Fernando René; 0000-0002-0464-8643; 7381
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final80
dc.pagina.inicio77
dc.revistaAnesthesia and Analgesia
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRemifentanil requirements during propofol administration to block the somatic response to skin incision in children and adults
dc.typeartículo
dc.volumen104
sipa.codpersvinculados73573
sipa.codpersvinculados79356
sipa.codpersvinculados817
sipa.codpersvinculados7381
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2024-08-19
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