Overweight and Obese Adult Patients Show Larger Benefits from Concurrent Training Compared with Pharmacological Metformin Treatment on Insulin Resistance and Fat Oxidation

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dc.contributor.authorAzocar-Gallardo, Jairo
dc.contributor.authorRamirez-Campillo, Rodrigo
dc.contributor.authorAfonso, Jose
dc.contributor.authorSa, Mario
dc.contributor.authorGranacher, Urs
dc.contributor.authorGonzalez-Rojas, Luis
dc.contributor.authorOjeda-Aravena, Alex
dc.contributor.authorManuel Garcia-Garcia, Jose
dc.date.accessioned2025-01-20T21:01:28Z
dc.date.available2025-01-20T21:01:28Z
dc.date.issued2022
dc.description.abstractMetformin, a drug widely used to treat insulin resistance, and training that combines aerobic and strength exercise modalities (i.e., concurrent training) may improve insulin sensitivity. However, there is a paucity of clinical trials investigating the effects of concurrent training, particularly on insulin resistance and fat oxidation in overweight and obese patients. Furthermore, only a few studies have compared the effects of concurrent training with metformin treatment. Therefore, the aim of this study was to examine the effects of a 12-week concurrent training program versus pharmaceutical treatment with metformin on maximum fat oxidation, glucose metabolism, and insulin resistance in overweight or obese adult patients. Male and female patients with insulin resistance were allocated by convenience to a concurrent training group (n = 7 (2 males); age = 32.9 +/- 8.3 years; body mass index = 30 +/- 4.0 kg center dot m(-2)) or a metformin group (n = 7 (2 males); age = 34.4 +/- 14.0 years; body mass index = 34.4 +/- 6.0 kg center dot m(-2)). Before and after the interventions, all participants were assessed for total body mass, body mass index, fat mass, fat-free mass, maximum oxygen consumption, maximal fat oxidization during exercise, fasting glucose, and insulin resistance through the homeostatic model assessment (HOMA-IR). Due to non-normal distribution of the variable maximal fat oxidation, the Mann-Whitney U test was applied and revealed better maximal fat oxidization (Delta = 308%) in the exercise compared with the metformin group (Delta = -30.3%; p = 0.035). All other outcome variables were normally distributed, and significant group-by-time interactions were found for HOMA-IR (p < 0.001, Delta = -84.5%), fasting insulin (p < 0.001, Delta = -84.6%), and increased maximum oxygen consumption (p = 0.046, Delta = 12.3%) in favor of the exercise group. Similar changes were found in both groups for the remaining dependent variables. Concurrent training seems to be more effective compared with pharmaceutical metformin treatment to improve insulin resistance and fat oxidation in overweight and obese adult patients with insulin resistance. The rather small sample size calls for more research in this area.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijerph192114331
dc.identifier.eissn1660-4601
dc.identifier.urihttps://doi.org/10.3390/ijerph192114331
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92892
dc.identifier.wosidWOS:000883521700001
dc.issue.numero21
dc.language.isoen
dc.revistaInternational journal of environmental research and public health
dc.rightsacceso restringido
dc.subjectresistance training
dc.subjectendurance training
dc.subjectmuscle strength
dc.subjecthuman physical conditioning
dc.subjectmusculoskeletal and neural physiological phenomena
dc.subjectexercise
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOverweight and Obese Adult Patients Show Larger Benefits from Concurrent Training Compared with Pharmacological Metformin Treatment on Insulin Resistance and Fat Oxidation
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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