Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study

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dc.contributor.authorValenzuela G.
dc.contributor.authorAlarcon-Andrade G.
dc.contributor.authorSchulze-Schiapacasse C.
dc.contributor.authorGarcia-Salum T.
dc.contributor.authorPardo-Roa C.
dc.contributor.authorLevican J.
dc.contributor.authorSerrano E.
dc.contributor.authorAvendano M.J.
dc.contributor.authorAlmonacid L.I.
dc.contributor.authorPoblete-Cardenas E.
dc.contributor.authorSalinas E.
dc.contributor.authorMunoz-Marcos A.
dc.contributor.authorMedina R.A.
dc.contributor.authorRodriguez R.
dc.contributor.authorManzur D.
dc.contributor.authorBarriga J.
dc.contributor.authorGutierrez M.
dc.contributor.authorGodoy L.
dc.contributor.authorAravena J.
dc.contributor.authorNicolaides I.
dc.contributor.authorMartinez E.
dc.contributor.authorGomez-Canobbio C.
dc.contributor.authorJofre M.
dc.contributor.authorSalinas A.
dc.contributor.authorLoza C.
dc.contributor.authorMunoz A.
dc.contributor.authorBarja S.
dc.contributor.authorCespedes P.
dc.contributor.authorBermudez S.
dc.contributor.authorDepaoli D.
dc.contributor.authorOrmazabal N.
dc.date.accessioned2024-01-31T14:30:13Z
dc.date.available2024-01-31T14:30:13Z
dc.date.issued2022
dc.description.abstract© 2022 World Obesity Federation.Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined. Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients. Methods: An observational study was conducted in three tertiary hospitals, including paediatric hospitalized patients with a confirmatory SARS-CoV-2 RT-PCR from March 2020 to December 2021. Obesity was defined according to WHO 2006 (0–2 years) and CDC 2000 (2–20 years) growth references. Short-term outcomes were intensive care unit admission, ventilatory support, superinfections, acute kidney injury, and mortality. Neurological, respiratory, and cardiological symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms were considered as post-acute sequalae. Adjusted linear, logistic regression and generalized estimating equations models were performed. Results: A total of 216 individuals were included, and 67 (31.02%) of them had obesity. Obesity was associated with intensive care unit admission (aOR = 5.63, CI95% 2.90–10.94), oxygen requirement (aOR = 2.77, CI95% 1.36–5.63), non-invasive ventilatory support (aOR = 6.81, CI95% 2.11–22.04), overall superinfections (aOR = 3.02 CI95% 1.45–6.31), and suspected bacterial pneumonia (aOR = 3.00 CI95% 1.44–6.23). For post-acute sequalae, obesity was associated with dyspnea (aOR = 9.91 CI95% 1.92–51.10) and muscle weakness (aOR = 20.04 CI95% 2.50–160.65). Conclusions: In paediatric hospitalized patients with COVID-19, severe short-term outcomes and post-acute sequelae are associated with obesity. Recognizing obesity as a key comorbidity is essential to develop targeted strategies for prevention of COVID-19 complications in children.
dc.description.funderCRIP
dc.description.funderDIDEMUC
dc.description.funderFLUOMICS Consortium
dc.description.funderNIH‐NIAD
dc.description.funderNational Institutes of Health
dc.description.funderNIAID
dc.description.funderFONDECYT
dc.description.funderPontificia Universidad Católica de Chile
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.fechaingreso.objetodigital2024-09-27
dc.format.extent14 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1111/ijpo.12980
dc.identifier.eisbn978-3-030-28856-3
dc.identifier.eissn2047-76310
dc.identifier.isbn978-3-030-28855-6
dc.identifier.issn20476310 20476302
dc.identifier.pubmedid36222077
dc.identifier.scopusidSCOPUS_ID:85140058619
dc.identifier.urihttps://doi.org/10.1111/ijpo.12980
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81131
dc.identifier.wosidWOS:000866088800001
dc.information.autorucFacultad de Medicina; Pardo Roa, Catalina; S/I; 225251
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final318
dc.pagina.inicio305
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG
dc.relation.ispartofPediatric Obesity
dc.revistaPediatric Obesity
dc.rightsacceso restringido
dc.subjectadolescent
dc.subjectchild
dc.subjectCOVID-19
dc.subjectintensive care units
dc.subjectobesity
dc.subjectpost-acute COVID-19 syndrome
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleShort-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study
dc.typeartículo
dc.volumen11
sipa.codpersvinculados225251
sipa.indexScopus
sipa.trazabilidadCarga SIPA;31-01-2024
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