ENDOTHELIN REDUCES MICROVASCULAR BLOOD-FLOW BY ACTING ON ARTERIOLES AND VENULES OF THE HAMSTER-CHEEK POUCH

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dc.contributor.authorBORIC, MP
dc.contributor.authorDONOSO, V
dc.contributor.authorFOURNIER, A
dc.contributor.authorSTPIERRE, S
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:22:59Z
dc.date.available2025-01-23T19:22:59Z
dc.date.issued1990
dc.description.abstractSuperfusion of the cheek pouch with 0.1-10 nM endothelin (E) produced a concentration-related reduction in the clearance of 22Na+ used as an indicator of microvascular plasma flow. The median effective concentration was about 2 nM. The time course of E action was also concentration related. Superfusion with 10 nM E for 10 min caused a greater than 80% reduction in 22Na+ clearance; the rate at which the action of E started was significantly faster than the rate at which its action ended. Recovery did not exceed 70% even though the tissue was superfused with drug-free buffer for 90 min. The E-induced reduction in 22Na+ clearance was associated with vasoconstriction, as determined by intravital microscopy. Arterioles by 4th branching order were more sensitive to E action than arterioles of 1st or 2nd order; however, the constriction lasted considerably longer in the latter vessels. E-induced venular constriction followed a pattern analogous to that of arterioles of the same category, with the exception that the finer venules responded the least. Pretreatment of the cheek pouch with 300 nM nifedipine diminished but did not abolish the 1 nM E-induced reduction in 22Na+ clearance, and the recovery of clerance upon E washout was not accelerated by nifedipine.
dc.fuente.origenWOS
dc.identifier.eissn1879-0712
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99142
dc.identifier.wosidWOS:A1990EK18400014
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final133
dc.pagina.inicio123
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleENDOTHELIN REDUCES MICROVASCULAR BLOOD-FLOW BY ACTING ON ARTERIOLES AND VENULES OF THE HAMSTER-CHEEK POUCH
dc.typeartículo
dc.volumen190
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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