Maternal and perinatal outcomes of a venous thromboembolism high-risk cohort using a multidisciplinary treatment approach

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dc.contributor.authorErnst, Daniel M.
dc.contributor.authorOporto, Joaquin I.
dc.contributor.authorZuniga, Pamela A.
dc.contributor.authorPereira, Jaime I.
dc.contributor.authorVera, Claudio M.
dc.contributor.authorCarvajal, Jorge A.
dc.date.accessioned2025-01-20T23:53:39Z
dc.date.available2025-01-20T23:53:39Z
dc.date.issued2021
dc.description.abstractObjective To evaluate the maternal and perinatal outcomes in a cohort of pregnant women at high risk of venous thromboembolism (VTE).
dc.description.abstractMethods Women at high risk of VTE were evaluated in a multidisciplinary program using a complete diagnostic workup, and specific prophylactic or therapeutic treatment.
dc.description.abstractResults Women were considered at high risk of VTE in 57% (85/148) because of prior (75) or current (10) thromboembolism, and in 27% (40/148) of the cases due to adverse obstetric history. Thrombophilia was diagnosed in 57% of the cases (85/148), either in patients with previous thromboembolism (48%, 41/85) or without a history of thrombosis (70%, 44/63). The most common thrombophilia was antiphospholipid syndrome in 34% (29/85) of the cases. Under respective prophylactic or therapeutic treatment, there were no VTE during pregnancy (0%, 0/148), whereas four events occurred during the puerperium (3%, 4/148). An adverse obstetric outcome was present in 5% (7/148) of all pregnancies, with four early spontaneous abortions (3%, 4/148) and three late miscarriages (2%, 3/148).
dc.description.abstractConclusion Pregnant women at high risk of VTE can be effectively managed using a risk-adapted treatment. Our results support prospective enrollment and a multidisciplinary assessment of VTE in high-risk pregnant women.
dc.fuente.origenWOS
dc.identifier.doi10.1002/ijgo.13628
dc.identifier.eissn1879-3479
dc.identifier.issn0020-7292
dc.identifier.urihttps://doi.org/10.1002/ijgo.13628
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94983
dc.identifier.wosidWOS:000619771900001
dc.issue.numero3
dc.language.isoen
dc.pagina.final507
dc.pagina.inicio500
dc.revistaInternational journal of gynecology & obstetrics
dc.rightsacceso restringido
dc.subjectacquired thrombophilias
dc.subjectantiphospholipid syndrome
dc.subjectlow&#8208
dc.subjectmolecular&#8208
dc.subjectweight heparin
dc.subjectperinatal outcome
dc.subjectpregnancy
dc.subjectthromboprophylaxis
dc.subjectvenous thromboembolism
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal and perinatal outcomes of a venous thromboembolism high-risk cohort using a multidisciplinary treatment approach
dc.typeartículo
dc.volumen154
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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