COMPARATIVE-STUDY OF SIZE, TOTAL PROTEIN, FIBRINOGEN AND 5-HT CONTENT OF HUMAN AND CANINE PLATELET DENSITY SUBPOPULATIONS

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dc.contributor.authorMEZZANO, D
dc.contributor.authorARANDA, E
dc.contributor.authorFORADORI, A
dc.date.accessioned2025-01-23T19:26:06Z
dc.date.available2025-01-23T19:26:06Z
dc.date.issued1986
dc.description.abstractThe size, total protein, fibrinogen and 5-HT content were evaluated in density subpopulations of human and canine platelets fractionated in linear arabinogalactan gradients. The methodology was assessed to ascertain that platelet separation was by density and to discard artifactual changes and platelet release during the procedure. EDTA or PGE1 increased the size of human PRP-platelets, but not of dog platelets. In humans, high density (HD) platelets were 1.26 times larger and contained 1.88 times more fibrinogen, 2.23 times more 5-HT and 1.37 times more protein than low density (LD) platelets; in dogs, these density cohorts did not differ in protein content, but LD platelets were 1.29 times larger and had 1.33 times more fibrinogen and 5-HT than HD platelets. These findings suggest that cell density is mostly dependent on the protein content per unit volume of platelets (and not on dense bodies). The differences in fibrinogen and 5-HT content between HD and LD cohorts in humans and dogs may be related to platelet age. The difference in volume between HD and LD platelets in dogs is of uncertain interpretation.
dc.fuente.origenWOS
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99565
dc.identifier.wosidWOS:A1986F306700012
dc.issue.numero3
dc.language.isoen
dc.pagina.final292
dc.pagina.inicio288
dc.revistaThrombosis and haemostasis
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCOMPARATIVE-STUDY OF SIZE, TOTAL PROTEIN, FIBRINOGEN AND 5-HT CONTENT OF HUMAN AND CANINE PLATELET DENSITY SUBPOPULATIONS
dc.typeartículo
dc.volumen56
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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