Functional consequences of lead and mercury exposomes in the heart

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dc.article.number101048
dc.contributor.authorFerreira G.
dc.contributor.authorSantander A.
dc.contributor.authorChavarria L.
dc.contributor.authorCardozo R.
dc.contributor.authorSavio F.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorNicolson G.L.
dc.date.accessioned2025-05-01T10:30:44Z
dc.date.available2025-05-01T10:30:44Z
dc.date.issued2021
dc.description.abstract© 2021 Elsevier LtdLead and mercury are heavy metals that are highly toxic to life forms. There are no known physiological processes that require them, and they do not have a particular threshold concentration to produce biologic damage. They are non-biodegradable, and they slowly accumulate in the environment in a dynamic equilibrium between air, water, soil, food, and living organisms. Their accumulation in the environment has been increasing over time, because they were not banned from use in anthropogenic industrial production. In their +2 cationic state they are powerful oxidizing agents with the ability to interfere significantly with processes that require specific divalent cations. Acute or chronic exposure to lead and mercury can produce multisystemic damage, especially in the developing nervous systems of children and fetuses, resulting in variety of neurological consequences. They can also affect the cardiovascular system and especially the heart, either directly through their action on cardiomyocytes or indirectly through their effects on innervation, humoral responses or blood vessel alterations. For example, heart function modified by these heavy metals are heart rate, contraction, excitability, and rhythm. Some cardiac molecular targets have been identified and characterized. The direct mechanisms of damage of these heavy metals on heart function are discussed. We conclude that exposome to these heavy metals, should be considered as a major relevant risk factor for cardiac diseases.
dc.description.funderInstitute for Molecular Medicine, CA , USA
dc.description.funderInstitute for Molecular Medicine, CA, USA
dc.description.funderPEDECIBA
dc.description.funderUniversidad de la Rep?blica, Montevideo, Uruguay
dc.description.funderUniversidad de la República, Montevideo, Uruguay
dc.description.funderANII
dc.description.funderUniversity of Groningen
dc.description.funderFONDECYT
dc.description.funderUniversity Medical Centre Groningen
dc.description.funderCSIC
dc.description.funderPontificia Universidad Católica de Chile
dc.format.extent815 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.mam.2021.101048
dc.identifier.eissn18729452
dc.identifier.issn18729452 00982997
dc.identifier.pubmedid34479262
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85118995260
dc.identifier.urihttps://doi.org/10.1016/j.mam.2021.101048
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103657
dc.identifier.wosidWOS:000775973200001
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final815
dc.pagina.inicio806
dc.relation.ispartofMolecular Aspects of Medicine
dc.revistaMolecular Aspects of Medicine
dc.rightsAcceso cerrado
dc.subjectCardiac
dc.subjectExposure
dc.subjectIntoxication
dc.subjectLead
dc.subjectMercury
dc.subjectPoisoning
dc.subject.ddc400
dc.subject.deweyLenguases_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleFunctional consequences of lead and mercury exposomes in the heart
dc.typeartículo
dc.volumen50
sipa.codpersvinculados1002656
sipa.codpersvinculados1002656
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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