Fertility outcomes in male adults with congenital hypogonadotropic hypogonadism treated during puberty with human chorionic gonadotropin and recombinant follicle stimulating hormone

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dc.catalogadorgjm
dc.contributor.authorGrob Lunecke, Francisca
dc.contributor.authorKeshwani, Rachna
dc.contributor.authorAngley, Eleanor
dc.contributor.authorZacharin, Margaret
dc.date.accessioned2024-04-08T19:18:30Z
dc.date.available2024-04-08T19:18:30Z
dc.date.issued2024
dc.description.abstractAim: Hormone replacement therapy with testosterone for pubertal induction in boys with congenital hypogonadotropic hypogonadism (CHH) achieves virilization but not spermatogenesis. By contrast, human chorionic gonadotropin (hCG) and recombinant follicle stimulating hormone (rFSH) provides both virilization and spermatogenesis. Fertility outcomes of boys treated with recombinant therapy during adolescence have been infrequently described. We report fertility induction and pregnancy outcomes in CHH patients treated with recombinant gonadotropins during puberty. Methods: Data of six subjects with CHH (nā€‰=ā€‰3 Kallmann syndrome & nā€‰=ā€‰3 Isolated hypogonadotropic hypogonadism) treated with hCG and FSH for pubertal induction were reviewed. Of these, five underwent subsequent fertility induction while one desired fertility at the end of pubertal induction. Results: Partners of all subjects achieved pregnancies using hCG and rFSH, all with full term live births. All infants were clinically normal. Conclusion: This study provides early evidence of proof of concept of use of gonadotropin induction of puberty being beneficial in subsequent fertility outcome.
dc.fechaingreso.objetodigital2024-04-08
dc.format.extent5 pƔginas
dc.fuente.origenORCID
dc.identifier.doi10.1111/jpc.16540
dc.identifier.eissn1440-1754
dc.identifier.issn1034-4810
dc.identifier.urihttps://doi.org/10.1111/jpc.16540
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84986
dc.identifier.wosidWOS:001196413600001
dc.information.autorucEscuela de Medicina; Grob Lunecke, Francisca; 0000-0001-7685-9311; 209562
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaJournal of Paediatrics and Child Health
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 DEED Attribution-NonCommercial-NoDerivs 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFertility
dc.subjectGonadotropin
dc.subjectHypogonadotropic hypogonadism
dc.subjectKallmann syndrome
dc.subjectPregnancy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFertility outcomes in male adults with congenital hypogonadotropic hypogonadism treated during puberty with human chorionic gonadotropin and recombinant follicle stimulating hormone
dc.typeartĆ­culo
sipa.codpersvinculados209562
sipa.trazabilidadORCID;2024-04-08
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