Placental mitochondrial impairment and its association with maternal metabolic dysfunction

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dc.catalogadorgrr
dc.contributor.authorGrismaldo, R. Adriana
dc.contributor.authorLuevano-Martinez, Luis A.
dc.contributor.authorReyes, Monserrat
dc.contributor.authorGarcia-Marquez, Grecia
dc.contributor.authorGarcia-Rivas, Gerardo
dc.contributor.authorSobrevia Luarte, Luis Alberto
dc.date.accessioned2024-08-22T22:00:24Z
dc.date.available2024-08-22T22:00:24Z
dc.date.issued2024
dc.description.abstractThe placenta plays an essential role in pregnancy, leading to proper fetal development and growth. As an organ with multiple physiological functions for both mother and fetus, it is a highly energetic and metabolically demanding tissue. Mitochondrial physiology plays a crucial role in the metabolism of this organ and thus any alteration leading to mitochondrial dysfunction has a severe outcome in the development of the fetus. Pregnancy-related pathological states with a mitochondrial dysfunction outcome include preeclampsia and gestational diabetes mellitus. In this review, we address the role of mitochondrial morphology, metabolism and physiology of the placenta during pregnancy, highlighting the roles of the cytotrophoblast and syncytiotrophoblast. We also describe the relationship between preeclampsia, gestational diabetes, gestational diabesity and pre-pregnancy maternal obesity with mitochondrial dysfunction. image, Abstract figure legend Diseases of pregnancy such as preeclampsia, gestational diabetes mellitus, pre-pregnancy maternal obesity and obesity in pregnancy result in dysfunctional mitochondria, leading to altered fetal development and growth with consequences for young and adulthood. Created with BioRender.com. image
dc.format.extent22 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1113/JP285935
dc.identifier.eissn1469-7793
dc.identifier.issn0022-3751
dc.identifier.pubmedid39116002
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85200984857
dc.identifier.urihttps://doi.org/10.1113/JP285935
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87638
dc.identifier.wosidWOS:001286008500001
dc.information.autorucEscuela de Medicina; Sobrevia Luarte, Luis Alberto; 0000-0001-5802-2243; 1002656
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherWILEY
dc.revistaJournal of Physiology-London
dc.rightsacceso restringido
dc.subjectGestational diabetes
dc.subjectMetabolic dysfunction
dc.subjectMitochondria
dc.subjectObesity
dc.subjectPlacenta
dc.subjectPreeclampsia
dc.subjectPregnancy
dc.subject610
dc.subject.ods03 Good health and well-being
dc.subject.ods02 Zero hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titlePlacental mitochondrial impairment and its association with maternal metabolic dysfunction
dc.typeartículo
sipa.codpersvinculados1002656
sipa.trazabilidadWOS;2024-08-17
sipa.trazabilidadORCID
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