Contribution of pro-inflammatory molecules induced by respiratory virus infections to neurological disorders

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dc.catalogadorvzp
dc.contributor.authorBohmwald Prieto, Karen
dc.contributor.authorAndrade Parra, Catalina Andrea
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-22T15:22:40Z
dc.date.available2024-01-22T15:22:40Z
dc.date.issued2021
dc.description.abstractNeurobehavioral alterations and cognitive impairment are common phenomena that represent neuropsychiatric disorders and can be triggered by an exacerbated immune response against pathogens, brain injury, or autoimmune diseases. Pro-inflammatory molecules, such as cytokines and chemokines, are produced in the brain by resident cells, mainly by microglia and astrocytes. Brain infiltrating immune cells constitutes another source of these molecules, contributing to an impaired neurological synapse function, affecting typical neurobehavioral and cognitive performance. Currently, there is increasing evidence supporting the notion that behavioral alterations and cognitive impairment can be associated with respiratory viral infections, such as human respiratory syncytial virus, influenza, and SARS-COV-2, which are responsible for endemic, epidemic, or pandemic outbreak mainly in the winter season. This article will review the brain0s pro-inflammatory response due to infection by three highly contagious respiratory viruses that are the leading cause of acute respiratory illness, morbidity, and mobility in infants, immunocompromised and elderly population. How these respiratory viral pathogens induce increased secretion of pro-inflammatory molecules and their relationship with the alterations at a behavioral and cognitive level will be discussed.
dc.description.funderCONICYT
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-01-22
dc.format.extent20 páginas
dc.fuente.origenScopus
dc.identifier.doi10.3390/ph14040340
dc.identifier.eissn14248247
dc.identifier.issn1424-8247
dc.identifier.scopusidSCOPUS_ID:85104521586
dc.identifier.urihttps://www.mdpi.com/1424-8247/14/4/340/pdf
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80874
dc.identifier.wosidWOS:000643408300001
dc.information.autorucFacultad de Ciencias Biológicas; Bohmwald Prieto Karen; 0000-0002-6794-7544; 1007746
dc.information.autorucFacultad de Ciencias Biológicas; Andrade Parra Catalina Andrea; 0000-0003-2623-1387; 234276
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final20
dc.pagina.inicio1
dc.publisherMDPI AG
dc.revistaPharmaceuticals
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution-NonCommercial License (BY-NC-4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBrain
dc.subjectNeuropsychiatric disorders
dc.subjectPro-inflammatory molecules
dc.subjectViral infection
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContribution of pro-inflammatory molecules induced by respiratory virus infections to neurological disorders
dc.typeartículo
dc.volumen14
sipa.codpersvinculados1007746
sipa.codpersvinculados234276
sipa.codpersvinculados90610
sipa.trazabilidadScopus;12-10-2021
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