INCREASE OF MUSCLE PEROXISOMAL ENZYMES AND MYOTONIA INDUCED BY NAFENOPIN, A HYPOLIPIDEMIC DRUG

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dc.contributor.authorBEHRENS, MI
dc.contributor.authorSOZA, MA
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:43:55Z
dc.date.available2025-01-23T19:43:55Z
dc.date.issued1983
dc.description.abstractThe chronic administration of nafenopin, a hypolipidemic drug, induced an increase in catalase and acyl-CoA oxidase activities in various rat skeletal muscles, including the gracilis, diaphragm, soleus and extensor digitorum longus. The magnitude of the increase was around 100% for both enzymes in each of the muscles studied in spite of the different basal level. These changes seem to be specific of the peroxisomal enzymes because acetylcholinesterase, which is not peroxisomal, did not follow the same pattern in all the muscles. Concomitant with the increase in muscle peroxisomal enzymes, the skeletal muscles presented an altered electromyogram with prolonged insertional activity, repetitive firing of action potentials and myotonic runs characteristic of myotonia. A role for peroxisomes in the myotonic disorder is suggested.
dc.fuente.origenWOS
dc.identifier.eissn1097-4598
dc.identifier.issn0148-639X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99874
dc.identifier.wosidWOS:A1983QJ95800010
dc.issue.numero2
dc.language.isoen
dc.pagina.final159
dc.pagina.inicio154
dc.revistaMuscle & nerve
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINCREASE OF MUSCLE PEROXISOMAL ENZYMES AND MYOTONIA INDUCED BY NAFENOPIN, A HYPOLIPIDEMIC DRUG
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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