Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice

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dc.contributor.authorTrigatti, B
dc.contributor.authorRigotti, A
dc.date.accessioned2024-01-10T12:42:19Z
dc.date.available2024-01-10T12:42:19Z
dc.date.issued2000
dc.description.abstractThe scavenger receptor BI is a cell surface lipoprotein receptor for selective high-density lipoprotein (HDL) cholesterol uptake in the liver and steroidogenic tissues. Studies of genetically manipulated strains of mice have revealed that SR-BI plays a key role in regulating HDL metabolism, cholesterol transport to steroidogenic tissues and bile cholesterol secretion. Furthermore, SR-BI protects against the development of atherosclerosis and is required for normal female fertility: If SR-BI has similar functions in lipoprotein metabolism and atherosclerosis in humans, it may represent a new target for the prevention and/or treatment of atherosclerotic cardiovascular disease.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.issn0250-0868
dc.identifier.pubmedidMEDLINE:10937352
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77501
dc.identifier.wosidWOS:000088504600001
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.issue.numero2-3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final37
dc.pagina.inicio29
dc.publisherBIOSCIENCE EDIPRINT INC
dc.revistaINTERNATIONAL JOURNAL OF TISSUE REACTIONS-EXPERIMENTAL AND CLINICAL ASPECTS
dc.rightsregistro bibliográfico
dc.subjectAPOPROTEIN-A-I
dc.subjectDIETARY-CHOLESTEROL
dc.subjectTARGETED MUTATION
dc.subjectAPOLIPOPROTEIN-E
dc.subjectSELECTIVE UPTAKE
dc.subjectTRANSGENIC MICE
dc.subjectADRENAL-CELLS
dc.subjectHUMAN HOMOLOG
dc.subjectHDL
dc.subjectRAT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleScavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice
dc.typeartículo
dc.volumen22
sipa.codpersvinculados68489
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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