AGING DIFFERENTIALLY MODIFIES ARTERIAL SENSITIVITY TO ENDOTHELIN-1 AND 5-HYDROXYTRYPTAMINE - STUDIES IN DOG CORONARY-ARTERIES AND RAT ARTERIAL MESENTERIC BED

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dc.contributor.authorDONOSO, MV
dc.contributor.authorFOURNIER, A
dc.contributor.authorPESCHKE, H
dc.contributor.authorFAUNDEZ, H
dc.contributor.authorDOMENECH, R
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:21:30Z
dc.date.available2025-01-23T19:21:30Z
dc.date.issued1994
dc.description.abstractThe influence of age on vascular reactivity to endothelin-1 (ET-1) and 5-hydroxytryptamine (5-HT) was studied in coronary artery rings from dogs of 9 years of age or younger, and dogs older than 9 years. ET-1 caused concentration-dependent contractions that developed about 100% of the 70 mM KCl-induced tension in the younger dogs; those from older dogs did not generate more than 20%. In contrast, 5-HT developed only about 20% of the KCl-induced tension in rings from young dogs, whereas in the older animals, it developed up to 120% of the KCl tension. No significant difference in the tension developed by 70 mM KCl was noted between both groups of dogs. Mechanical denudation of the endothelial cell layer caused a modest, yet significant, leftward shift of the ET-1 and 5-HT concentration-response curves only in the younger dogs. N omega-Nitro-L-arginine (15 mu M) shifted the ET-1 concentration-response curves to the left in rings from both groups of dogs. Rings precontracted with 20 mM KCl relaxed in a concentration-dependent fashion with acetylcholine; its sensitivity was about threefold less in the older group of dogs. To validate the changes in Vascular reactivity with age, a parallel study was performed perfusing the arterial mesenteric bed of rats of 3, 7, and 30 weeks of age. In this experimental model, the efficacy of ET-1 significantly decreased with age and that of 5-HT was significantly increased. The vasomotor reactivity of noradrenaline was modestly affected by aging, whereas the acetylcholine-induced vasorelaxation was significantly reduced with age.
dc.fuente.origenWOS
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98787
dc.identifier.wosidWOS:A1994PW73700023
dc.issue.numero8
dc.language.isoen
dc.pagina.final1495
dc.pagina.inicio1489
dc.revistaPeptides
dc.rightsacceso restringido
dc.subjectENDOTHELIN-1
dc.subjectAGING AND VASOMOTOR REACTIVITY
dc.subjectDOG CORONARY CIRCULATION
dc.subjectCORONARY RINGS
dc.subject5-HT VASCULAR RECEPTORS
dc.subjectACETYLCHOLINE
dc.subjectENDOTHELIUM
dc.subjectN-OMEGA-NITRO-L-ARGININE
dc.subjectRAT MESENTERIC ARTERIAL BED
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAGING DIFFERENTIALLY MODIFIES ARTERIAL SENSITIVITY TO ENDOTHELIN-1 AND 5-HYDROXYTRYPTAMINE - STUDIES IN DOG CORONARY-ARTERIES AND RAT ARTERIAL MESENTERIC BED
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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