PRIMARY HYPERPARATHYROIDISM AND HYPERTENSION - PERSISTENTLY ABNORMAL PRESSOR SENSITIVITY IN NORMOTENSIVE PATIENTS AFTER SURGICAL CURE

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dc.contributor.authorRODRIGUEZPORTALES, JA
dc.contributor.authorFARDELLA, C
dc.date.accessioned2025-01-21T01:35:32Z
dc.date.available2025-01-21T01:35:32Z
dc.date.issued1994
dc.description.abstractTo examine the effects of primary hyperparathyroidism separately from those of hypertension per se on blood pressure regulation in patients with primary hyperparathyroidism, we studied the presser response to infused angiotensin II (All) and to norepinephrine (NE) in 7 normotensive patients with primary hyperparathyroidism before and after surgical cure, and compared it to that observed in 10 subjects with idiopathic hypertension and 10 normal controls. While the subjects were on an ad libitum diet, we measured urinary and plasma electrolytes, creatinine, and plasma renin activity. Except for calcium, these values were not significantly different among the three groups. The blood pressure was measured basally and in response to graded doses of All or of NE until a 20-mmHg increase in the diastolic blood pressure was reached (''pressor dose''). The presser doses of All and of NE were lower in the normotensive patients with primary hyperparathyroidism than in normal controls [4.6 +/- 2.0 vs. 7.3 +/- 3.5 ng/kg/min (p<0.05) and 164 +/- 114 vs. 302 +/- 176 ng/kg/min (p<0.05) respectively] and not significantly different from those found in idiopathic hypertension (3.1 +/- 1.2 and 137 +/- 95 ng/kg/min). When the patients with primary hyperparathyroidism were studied again between 2-6 months after surgical cure, their presser doses of All and of NE remained unchanged from their preoperative values (5.4 +/- 2.9 and 137 +/- 80 mg/kg/min). We conclude that the hyperparathyroid condition can disrupt the normal responsiveness to presser agents even if the blood pressure remains within normal limits, and that this abnormality may persist after surgical cure.
dc.fuente.origenWOS
dc.identifier.issn0391-4097
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97692
dc.identifier.wosidWOS:A1994NR65900002
dc.issue.numero5
dc.language.isoen
dc.pagina.final311
dc.pagina.inicio307
dc.revistaJournal of endocrinological investigation
dc.rightsacceso restringido
dc.subjectHYPERPARATHYROIDISM
dc.subjectHYPERTENSION
dc.subjectCALCIUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePRIMARY HYPERPARATHYROIDISM AND HYPERTENSION - PERSISTENTLY ABNORMAL PRESSOR SENSITIVITY IN NORMOTENSIVE PATIENTS AFTER SURGICAL CURE
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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