Exploring the impact of<i> Agaricus</i><i> bisporus</i> on mitigating lead reproductive toxicity using the<i> Caenorhabditis</i><i> elegans</i> model
| dc.contributor.author | Caetano, Erika Leao Ajala | |
| dc.contributor.author | Miguel, Francisco Javier Novoa San | |
| dc.contributor.author | Leon, Rocio Errazuriz | |
| dc.contributor.author | Grotto, Denise | |
| dc.contributor.author | Carneiro, Maria Fernanda Hornos | |
| dc.date.accessioned | 2025-01-20T16:04:48Z | |
| dc.date.available | 2025-01-20T16:04:48Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Given that Agaricus bisporus, an edible mushroom, has demonstrated antioxidant properties, our investigation aimed to assess whether Agaricus bisporus could mitigate the toxic effects of lead (Pb) on Caenorhabditis elegans (C. elegans) model. A dose-response study was conducted involving Pb and Agaricus bisporus to determine appropriate doses. Subsequently, a co-exposure study utilizing C. elegans strains N2 and CL2166 was implemented, with groups designated as Control, Pb, Agaricus bisporus, and Pb + Agaricus bisporus. Our findings revealed that co-exposure to Pb + 100 mg/mL Agaricus bisporus resulted in reduced embryonic and larval lethality, increased brood size, and enhanced motility compared to nematodes exposed solely to Pb. Notably, our observations indicated a transfer of reproductive toxicity from nematode parents to their offspring. Thus, Agaricus bisporus may play a significant role in Pb detoxification, suggesting its potential as a natural antioxidant for neutralizing the detrimental effects of Pb on reproductive health. | |
| dc.fuente.origen | WOS | |
| dc.identifier.doi | 10.1016/j.cbpc.2024.109963 | |
| dc.identifier.eissn | 1878-1659 | |
| dc.identifier.issn | 1532-0456 | |
| dc.identifier.uri | https://doi.org/10.1016/j.cbpc.2024.109963 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/89849 | |
| dc.identifier.wosid | WOS:001346677600001 | |
| dc.language.iso | en | |
| dc.revista | Comparative biochemistry and physiology c-toxicology & pharmacology | |
| dc.rights | acceso restringido | |
| dc.subject | Alternative animal models | |
| dc.subject | Agaricus bisporus | |
| dc.subject | Caenorhabditis elegans | |
| dc.subject | Lead | |
| dc.title | Exploring the impact of<i> Agaricus</i><i> bisporus</i> on mitigating lead reproductive toxicity using the<i> Caenorhabditis</i><i> elegans</i> model | |
| dc.type | artículo | |
| dc.volumen | 283 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |