Simultaneous 3D aortic lumen and vessel wall imaging at 0.55 T at either systole or diastole

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dc.catalogadorpva
dc.contributor.authorParedes Gálvez, Matías Ignacio
dc.contributor.authorCastillo Passi, Carlos
dc.contributor.authorKunze, Karl P.
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorLittlewood, Simon
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2025-07-01T21:47:12Z
dc.date.available2025-07-01T21:47:12Z
dc.date.issued2025
dc.description.abstractPurpose: To evaluate the feasibility of a novel, non-contrast enhanced, 3D, simultaneous bright-blood, and black-blood sequence (iT2prep-BOOST) for aortic imaging at 0.55 T at either systole or diastole. Methods: Simultaneous contrast-free 3D aortic lumen and vessel wall imaging at 0.55 T is achieved using the recently introduced iT2prep-BOOST framework that interleaves the acquisition of two bright blood images (with inversion recovery T-2 preparation [T2prep-IR] and no preparation). To enable either systolic or diastolic aortic imaging, three T-2 preparation pulses were investigated-an adiabatic RF pulse and two Malcolm-Levitt (MLEV) pulses (MLEV4 and MLEV8)-to improve image quality in regions with high flow and susceptibility. The proposed approach was evaluated in phantom, 10 healthy subjects and 3 patients with suspected cardiovascular disease. Bright- and black-blood images resulting from the three different T-2 preparation pulses were compared both qualitatively and quantitatively, using a 4-point Likert scale for vessel sharpness and presence of blood artifacts. Additionally, the contrast ratio between the lumen and myocardium was computed. Aortic measurements, including the aortic annulus area at systole and diastole, cusp-commissure measurement at the aortic root level during diastole, and aortic diameter at the ascending aortic level during diastole were also performed. Results: Excellent or good image quality scores were obtained for both bright- and black-blood images with iT2prep-BOOST at 0.55 T with all three preparation pulses. The use of MLEV8 T-2 preparation scheme improves systolic image quality, reducing the presence of artifacts with a significant difference (p < 0.05) at the mid descending aorta level. This scheme also increases the contrast ratio between aortic lumen and myocardium, compared to the previously used adiabatic RF T-2 preparation. The aortic root diameter and area were consistent with values reported in the literature for healthy subjects at 1.5 T. Conclusion: The feasibility of a novel, non-contrast-enhanced, 3D aortic imaging framework for simultaneous bright-blood and black-blood imaging was demonstrated at 0.55 T for either systole or diastole, with a scan time of 7 min. Good image quality scores and aortic measurements in agreement with literature values at 1.5 T were achieved with the MLEV8 T-2 preparation. Studies in a larger cohort of healthy subjects and patients with aortopathies are warranted.
dc.description.funderANID FONDECYT
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.30611
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1002/mrm.30611
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104816
dc.identifier.wosidWOS:001513255400001
dc.information.autorucEscuela de Ingeniería; Paredes Gálvez, Matías Ignacio; S/I; 245348
dc.information.autorucEscuela de Ingeniería; Castillo Passi, Carlos; 0000-0001-6227-0477; 204150
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherJohn Wiley & Sons
dc.revistaMagnetic Resonance in Medicine
dc.rightsacceso restringido
dc.subjectAortic MRI
dc.subjectBright and black blood
dc.subjectFree-breathing
dc.subjectLow-field
dc.subjectLumen
dc.subjectSystole and diastole
dc.subjectVessel wall
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous 3D aortic lumen and vessel wall imaging at 0.55 T at either systole or diastole
dc.typeartículo
sipa.codpersvinculados245348
sipa.codpersvinculados204150
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadWOS;2025-06-28
sipa.trazabilidadORCID;2025-06-30
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