Extracellular matrix collagen synthesis and degradation following coronary balloon angioplasty

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dc.contributor.authorGuarda, E
dc.contributor.authorKatwa, LC
dc.contributor.authorCampbell, SE
dc.contributor.authorTanner, MA
dc.contributor.authorWebel, RM
dc.contributor.authorLaughlin, H
dc.contributor.authorJenkins, S
dc.contributor.authorMyers, PR
dc.date.accessioned2025-01-21T01:34:04Z
dc.date.available2025-01-21T01:34:04Z
dc.date.issued1996
dc.description.abstractPercutaneous transluminal coronary angioplasty is associated with intimal hyperplasia and extracellular matrix deposition of collagen, leading to restenosis in a significant number of cases. The purpose of the present study was to determine the effects of balloon angioplasty on extracellular matrix collagen content and collagenase activity in a porcine coronary artery restenosis model 6 weeks following balloon injury. We tested the hypothesis that in balloon-injured arteries the neointimal extracellular matrix was characterized by increased collagen content and decreased metalloproteinase activity relative to non-injured arteries. Male miniswine maintained on a high cholesterol diet underwent cardiac catheterization and double balloon injury to the right and left circumflex coronary arteries. The coronary arteries were either pressure-perfusion-fixed and prepared for histological examination, or dissected free of adventitia for further collagen and matrix metalloproteinase studies. Collagen synthesis in balloon-injured coronary arteries was compared to non-injured arteries using Northern blot analysis and histochemical stains. Comparative studies on differences between balloon-injured and non-balloon-injured arterial matrix metalloproteinase activity were done using zymography. Balloon angioplasty arterial injury resulted in a significant increase in type I collagen mRNA expression, with increased collagen deposition in the extracellular matrix. In contrast, matrix metalloproteinase activity was markedly decreased. The results suggest that the increased neointimal extracellular matrix observed late in the injury response may be due to not only increased collagen synthesis, but also reduced degradation. The failure to achieve a balance between the synthesis and degradation of extracellular matrix collagen could serve as an important mechanism responsible for restenosis. (C) 1996 Academic Press Limited
dc.fuente.origenWOS
dc.identifier.eissn1095-8584
dc.identifier.issn0022-2828
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97511
dc.identifier.wosidWOS:A1996UG27000005
dc.issue.numero4
dc.language.isoen
dc.pagina.final706
dc.pagina.inicio699
dc.revistaJournal of molecular and cellular cardiology
dc.rightsacceso restringido
dc.subjectrestenosis
dc.subjectextracellular matrix
dc.subjectmetalloproteinase
dc.subjectcollagenase
dc.subjectcollagen
dc.subjectPTCA
dc.subjectpercutaneous transluminal coronary angioplasty
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracellular matrix collagen synthesis and degradation following coronary balloon angioplasty
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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