Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure

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dc.catalogadorvdr
dc.contributor.authorAlcantara, Juan M. A.
dc.contributor.authorSanchez-Delgado, Guillermo
dc.contributor.authorJurado-Fasoli, Lucas
dc.contributor.authorGalgani Fuentes, José
dc.contributor.authorLabayen, Idoia
dc.contributor.authorRuiz, Jonatan R.
dc.date.accessioned2024-10-17T13:05:35Z
dc.date.available2024-10-17T13:05:35Z
dc.date.issued2022
dc.description.abstractMetabolic flexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric correction of metabolic cart readouts improves day-to-day reproducibility. The EE was assessed (12 young adults, 6 women, 27 +/- 2 years old) using an Omnical metabolic cart (Maastricht Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was determined. We observed a high day-to-day reproducibility for the assessed RER (coefficients of variation [CV] <4%) and EE (CVs < 9%) in the 7 different periods. In contrast, the RER and EE areas under the curve showed a low day-to-day reproducibility (CV = 22% and 56%, respectively). Contrary to our expectations, the postcalorimetric correction procedure did not influence the day-to-day reproducibility of the energy metabolism response, possibly because the Omnical's accuracy was similar to 100%. Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs >20%) even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not influence the day-to-day reproducibility.
dc.fechaingreso.objetodigital2024-10-17
dc.fuente.origenWOS
dc.fuente.origenORCID;2024-10-14
dc.identifier.doi10.1007/s00394-022-02986-w
dc.identifier.eissn1436-6215
dc.identifier.issn1436-6207
dc.identifier.urihttp://doi.org/10.1007/s00394-022-02986-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88274
dc.identifier.wosidWOS:000844487300001
dc.information.autorucEscuela de Medicina; Galgani Fuentes, José; 0000-0001-9793-8561; 1011272
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final361
dc.pagina.inicio351
dc.revistaEUROPEAN JOURNAL OF NUTRITION
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIndirect calorimetry
dc.subjectReliability
dc.subjectPostprandial metabolism
dc.subjectGlucose tolerance
dc.subjectMetabolic cart
dc.subjectIndirect calorimetry
dc.subjectReliability
dc.subjectPostprandial metabolism
dc.subjectGlucose tolerance
dc.subjectMetabolic cart
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure
dc.typeartículo
dc.volumen62
sipa.codpersvinculados1011272
sipa.trazabilidadWOS;2022-10-11
sipa.trazabilidadORCID;2024-10-14
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