Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

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dc.contributor.authorDiniz, Mariana S.
dc.contributor.authorHiden, Ursula
dc.contributor.authorFalcao-Pires, Ines
dc.contributor.authorOliveira, Paulo J.
dc.contributor.authorSobrevia, Luis
dc.contributor.authorPereira, Susana P.
dc.date.accessioned2025-01-20T17:37:51Z
dc.date.available2025-01-20T17:37:51Z
dc.date.issued2023
dc.description.abstractGestational diabetes mellitus (GDM) and maternal obesity (MO) increase the risk of adverse fetal outcomes, and the incidence of cardiovascular disease later in life. Extensive research has been conducted to elucidate the underlying mechanisms by which GDM and MO program the offspring to disease. This review focuses on the role of fetoplacental endothelial dysfunction in programming the offspring for cardiovascular disease in GDM and MO pregnancies. We discuss how pre-existing maternal health conditions can lead to vascular dysfunction in the fetoplacental unit and the fetus. We also examine the role of fetoplacental endothelial dysfunction in impairing fetal cardiovascular system development and the involvement of nitric oxide and hydrogen sulfide in mediating fetoplacental vascular dysfunction. Furthermore, we suggest that the L-Arginine-Nitric Oxide and the AdenosineL-Arginine-Nitric Oxide (ALANO) signaling pathways are pertinent targets for research. Despite significant progress in this area, there are still knowledge gaps that need to be addressed in future research.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbadis.2023.166834
dc.identifier.eissn1879-260X
dc.identifier.issn0925-4439
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2023.166834
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91697
dc.identifier.wosidWOS:001067511400001
dc.issue.numero8
dc.language.isoen
dc.revistaBiochimica et biophysica acta-molecular basis of disease
dc.rightsacceso restringido
dc.subjectGestational diabesity
dc.subjectMetabolic syndrome
dc.subjectEndothelial dysfunction
dc.subjectCardiac function
dc.subjectFetal development
dc.subjectAdenosine receptors
dc.subjectNitric oxide
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
dc.typeartículo
dc.volumen1869
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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