Efficacy of hepatitis A vaccination in children aged 12 to 24 months

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dc.contributor.authorAbarca, K
dc.contributor.authorIbañez, I
dc.contributor.authorFlores, J
dc.contributor.authorVial, PA
dc.contributor.authorSafary, A
dc.contributor.authorPotín, M
dc.date.accessioned2025-01-21T01:30:43Z
dc.date.available2025-01-21T01:30:43Z
dc.date.issued2001
dc.description.abstractBackground. Current hepatitis A vaccines are either licensed for children >2 years of age. as in the U.S. or Chile, or >1 year of age, as in Europe and other parts of the world. Recent recommendations for immunization against hepatitis A have included routine vaccination of children in areas or regions of higher endemicity. However, data on hepatitis A vaccination in toddlers aged between 1 and 2 years are scarce.
dc.description.abstractMethods. This open clinical study investigated the reactogenicity and immunogenicity of two doses (0, 6-month schedule) of an inactivated hepatitis A vaccine (Havrix((TM)) pediatric, Glaxco SmithKline Biologicals, Rixensart, Belgium) in 120 seronegative children aged 12-24 months.
dc.description.abstractResults. Pain at the injection site and irritability were the most frequently reported local and general symptoms, respectively. No serious adverse events related to the study vaccine were reported. One month after the first dose, all but one subject had antibodies against hepatitis A with a GMT of 159 mIU/mL. After the booster dose., all had antibodies with a GMT of 2,939 mIU/mL.
dc.description.abstractConclusions. Our data show that the inactivated hepatitis A vaccine was well tolerated by these toddlers and that the vaccine elicits a good immune response. (C) 2001 IMSS. Published by Elsevier Science Inc.
dc.fuente.origenWOS
dc.identifier.eissn1873-5487
dc.identifier.issn0188-4409
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96871
dc.identifier.wosidWOS:000171187900016
dc.issue.numero5
dc.language.isoen
dc.pagina.final472
dc.pagina.inicio468
dc.revistaArchives of medical research
dc.rightsacceso restringido
dc.subjectimmunization
dc.subjectchildhood vaccination
dc.subjecttoddlers
dc.subjectliver disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEfficacy of hepatitis A vaccination in children aged 12 to 24 months
dc.typeartículo
dc.volumen32
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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