Nerve regeneration in Wld<SUP>s</SUP> mice is normalized by actinomycin D

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dc.contributor.authorCourt, F
dc.contributor.authorAlvarez, J
dc.date.accessioned2025-01-21T01:31:19Z
dc.date.available2025-01-21T01:31:19Z
dc.date.issued2000
dc.description.abstractInjured nerves of Wld(s) mice neither degenerate nor regenerate for several weeks. We have conjectured that Wld(s) axons have the ability to regenerate but its expression is impaired by the Schwann cells of the undegenerated distal stump. To test this conjecture, transcription was locally arrested with actinomycin D (ActD), nerves were crushed, and regrowth was evaluated. In normal CD1 nerves injected with ActD 3 days before the crush. the rate of elongation was not affected but the delay of regrowth was shortened. In sharp contrast, ActD normalized the elongation of Wld(s) axons. When Wld(s) nerves were crushed past the treated segment, axons did not regenerate. After 7, but not 4, days of treatment, intact CD1 and Wld(s) axons presented a local sprouting response. We conclude that Wld(s) axons can regenerate in a normal way but do not do so because the undegenerated Schwann cells of the distal stump repress the regrowth program. We present a model axon that includes a destruction program and a post-transcriptional trophic regulation of its phenotype. (C) 2000 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97036
dc.identifier.wosidWOS:000087672300001
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final8
dc.pagina.inicio1
dc.revistaBrain research
dc.rightsacceso restringido
dc.subjecttranscription
dc.subjectsprouting
dc.subjectschwann cell
dc.subjecttrophism
dc.subjectdegeneration
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNerve regeneration in Wld<SUP>s</SUP> mice is normalized by actinomycin D
dc.typeartículo
dc.volumen867
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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