Genome-wide association study identifies eight loci associated with blood pressure

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dc.contributor.authorNewton-Cheh, Christopher
dc.contributor.authorJohnson, Toby
dc.contributor.authorGateva, Vesela
dc.contributor.authorTobin, Martin D.
dc.contributor.authorBochud, Murielle
dc.contributor.authorCoin, Lachlan
dc.contributor.authorNajjar, Samer S.
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorHeath, Simon C.
dc.contributor.authorEyheramendy, Susana
dc.contributor.authorPapadakis, Konstantinos
dc.contributor.authorVoight, Benjamin F.
dc.contributor.authorScott, Laura J.
dc.contributor.authorZhang, Feng
dc.contributor.authorFarrall, Martin
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorWallace, Chris
dc.contributor.authorChambers, John C.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorNilsson, Peter
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorPolidoro, Silvia
dc.contributor.authorGrobbee, Diederick E.
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorBots, Michiel L.
dc.contributor.authorWain, Louise V.
dc.contributor.authorElliott, Katherine S.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorLuan, Jian'an
dc.contributor.authorLucas, Gavin
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorBurton, Paul R.
dc.contributor.authorHadley, David
dc.contributor.authorMcArdle, Wendy L.
dc.contributor.authorBrown, Morris
dc.contributor.authorDominiczak, Anna
dc.contributor.authorNewhouse, Stephen J.
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorWebster, John
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorBeckmann, Jacques S.
dc.contributor.authorBergmann, Sven
dc.contributor.authorLim, Noha
dc.contributor.authorSong, Kijoung
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWaeber, Gerard
dc.contributor.authorWaterworth, Dawn M.
dc.contributor.authorYuan, Xin
dc.contributor.authorGroop, Leif
dc.contributor.authorOrho-Melander, Marju
dc.contributor.authorAllione, Alessandra
dc.contributor.authorDi Gregorio, Alessandra
dc.contributor.authorGuarrera, Simonetta
dc.contributor.authorPanico, Salvatore
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorRomanazzi, Valeria
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorVineis, Paolo
dc.contributor.authorBarroso, Ines
dc.contributor.authorSandhu, Manjinder S.
dc.contributor.authorLuben, Robert N.
dc.contributor.authorCrawford, Gabriel J.
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorPerola, Markus
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBonnycastle, Lori L.
dc.contributor.authorCollins, Francis S.
dc.contributor.authorJackson, Anne U.
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorStringham, Heather M.
dc.contributor.authorValle, Timo T.
dc.contributor.authorWiller, Cristen J.
dc.contributor.authorBergman, Richard N.
dc.contributor.authorMorken, Mario A.
dc.contributor.authorDoering, Angela
dc.contributor.authorGieger, Christian
dc.contributor.authorIllig, Thomas
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorOrg, Elin
dc.contributor.authorPfeufer, Arne
dc.contributor.authorWichmann, H. Erich
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorMarrugat, Jaume
dc.contributor.authorO'Donnell, Christopher J.
dc.contributor.authorSchwartz, Stephen M.
dc.contributor.authorSiscovick, David S.
dc.contributor.authorSubirana, Isaac
dc.contributor.authorFreimer, Nelson B.
dc.contributor.authorHartikainen, Anna-Liisa
dc.contributor.authorMcCarthy, Mark I.
dc.contributor.authorO'Reilly, Paul F.
dc.contributor.authorPeltonen, Leena
dc.contributor.authorPouta, Anneli
dc.contributor.authorde Jong, Paul E.
dc.contributor.authorSnieder, Harold
dc.contributor.authorvan Gilst, Wiek H.
dc.contributor.authorClarke, Robert
dc.contributor.authorGoel, Anuj
dc.contributor.authorHamsten, Anders
dc.contributor.authorPeden, John F.
dc.contributor.authorSeedorf, Udo
dc.contributor.authorSyvanen, Ann-Christine
dc.contributor.authorTognoni, Giovanni
dc.contributor.authorLakatta, Edward G.
dc.contributor.authorSanna, Serena
dc.contributor.authorScheet, Paul
dc.contributor.authorSchlessinger, David
dc.contributor.authorScuteri, Angelo
dc.contributor.authorDoerr, Marcus
dc.contributor.authorErnst, Florian
dc.contributor.authorFelix, Stephan B.
dc.contributor.authorHomuth, Georg
dc.contributor.authorLorbeer, Roberto
dc.contributor.authorReffelmann, Thorsten
dc.contributor.authorRettig, Rainer
dc.contributor.authorVoelker, Uwe
dc.contributor.authorGalan, Pilar
dc.contributor.authorGut, Ivo G.
dc.contributor.authorHercberg, Serge
dc.contributor.authorLathrop, G. Mark
dc.contributor.authorZelenika, Diana
dc.contributor.authorDeloukas, Panos
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorWilliams, Frances M.
dc.contributor.authorZhai, Guangju
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorLaakso, Markku
dc.contributor.authorElosua, Roberto
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorVolzke, Henry
dc.contributor.authorUiterwaal, Cuno S.
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorNumans, Mattijs E.
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorNavis, Gerjan
dc.contributor.authorBerglund, Goran
dc.contributor.authorBingham, Sheila A.
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorConnell, John M.
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorWatkins, Hugh
dc.contributor.authorSpector, Tim D.
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorAltshuler, David
dc.contributor.authorStrachan, David P.
dc.contributor.authorLaan, Maris
dc.contributor.authorMeneton, Pierre
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorUda, Manuela
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorMooser, Vincent
dc.contributor.authorMelander, Olle
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorElliott, Paul
dc.contributor.authorAbecasis, Goncalo R.
dc.contributor.authorCaulfield, Mark
dc.contributor.authorMunroe, Patricia B.
dc.date.accessioned2025-01-21T00:08:58Z
dc.date.available2025-01-21T00:08:58Z
dc.date.issued2009
dc.description.abstractElevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
dc.fuente.origenWOS
dc.identifier.doi10.1038/ng.361
dc.identifier.eissn1546-1718
dc.identifier.issn1061-4036
dc.identifier.urihttps://doi.org/10.1038/ng.361
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95690
dc.identifier.wosidWOS:000266411700015
dc.issue.numero6
dc.language.isoen
dc.pagina.final676
dc.pagina.inicio666
dc.revistaNature genetics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenome-wide association study identifies eight loci associated with blood pressure
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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