The nucleus pretectalis principalis: A pretectal structure hidden in the mammalian thalamus

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dc.contributor.authorDeichler, Alfonso
dc.contributor.authorCarrasco, Denisse
dc.contributor.authorGonzalez-Cabrera, Cristian
dc.contributor.authorLetelier, Juan C.
dc.contributor.authorMarin, Gonzalo
dc.contributor.authorMpodozis, Jorge
dc.date.accessioned2025-01-23T21:19:44Z
dc.date.available2025-01-23T21:19:44Z
dc.date.issued2019
dc.description.abstractA defining feature of the amniote tecto-fugal visual pathway is a massive bilateral projection to the thalamus originating from a distinct neuronal population, tectal ganglion cells (TGCs), of the optic tectum/superior colliculus (TeO/SC). In sauropsids, the thalamic target of the tecto-fugal pathway is the nucleus rotundus thalami (Rt). TGCs axons collateralize en route to Rt to target the nucleus pretectalis principalis (PT), which in turn gives rise to bilateral projection to the TeO. In rodents, the thalamic target of these TGCs afferents is the caudal division of the pulvinar complex (PulC). No pretectal structures in receipt of TGC collaterals have been described in this group. However, Baldwin et al. (Journal of Comparative Neurology, 2011;519(6):1071-1094) reported in the squirrel a feedback projection from the PulC to the SC. Pulvino-tectal (Pul-T) cells lie at the caudal pole of the PulC, intermingled with the axonal terminals of TGCs. Here, by performing a combination of neuronal tracing, immunohistochemistry, immunofluorescence, and in situ hybridization, we characterized the pattern of projections, neurochemical profile, and genoarchitecture of Pul-T cells in the diurnal Chilean rodent Octodon degus. We found that Pul-T neurons exhibit pretectal, but not thalamic, genoarchitectonical markers, as well as hodological and neurochemical properties that match specifically those of the avian nucleus PT. Thus, we propose that Pul-T cells constitute a pretectal cell population hidden within the dorsal thalamus of mammals. Our results solve the oddity entailed by the apparent existence of a noncanonic descending sensory thalamic projection and further stress the conservative character of the tectofugal pathway.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.fuente.origenWOS
dc.identifier.doi10.1002/cne.24540
dc.identifier.eissn1096-9861
dc.identifier.issn0021-9967
dc.identifier.urihttps://doi.org/10.1002/cne.24540
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101190
dc.identifier.wosidWOS:000454602400003
dc.issue.numero2
dc.language.isoen
dc.pagina.final391
dc.pagina.inicio372
dc.revistaJournal of comparative neurology
dc.rightsacceso restringido
dc.subjectbirds
dc.subjectmammals
dc.subjectpulvinar complex, pretectum
dc.subjectRRID: AB_10013220
dc.subjectRRID: AB_1566510
dc.subjectRRID: AB_2187693
dc.subjectRRID: AB_2239153
dc.subjectRRID: AB_2336654
dc.subjectRRID: AB_448990
dc.subjectRRID: AB_528426
dc.subjectRRID: AB_528428
dc.subjecttectofugal system
dc.subjectthalamus
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe nucleus pretectalis principalis: A pretectal structure hidden in the mammalian thalamus
dc.typeartículo
dc.volumen527
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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