Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents

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dc.catalogadorgjm
dc.contributor.authorOrtiz Perez, Eyra
dc.contributor.authorRivera, Gildardo
dc.contributor.authorSalas Sánchez, Cristián Osvaldo
dc.contributor.authorZarate Ramos, Juan J.
dc.contributor.authorTrofymchuk, Oleksandra S.
dc.contributor.authorHernandez Soberanis, Lucio
dc.contributor.authorPerales Flores, Juanita D.
dc.contributor.authorVazquez, Karina
dc.date.accessioned2025-03-20T18:24:14Z
dc.date.available2025-03-20T18:24:14Z
dc.date.issued2021
dc.description.abstractBackground: Naphthoquinones are a class of aromatic compounds relevant for their chemical characteristics, structural properties, and biological activity. These compounds are found in nature with a wide range of effects, highlighting their antibacterial, antifungal, and antiprotozoal properties. Additionally, naphthoquinones are used as a scaffold to obtain new derivatives with pharmacological potential, mainly compounds against parasitic diseases. Objective: The purpose of this work was to carry out a comprehensive review of naphthoquinones and their derivatives obtained from both natural and synthetic sources, also, to analyze their biological activity against Leishmania spp. (Leishmaniasis), Trypanosoma cruzi (Chagas disease), Plasmodium falciparum (Malaria), Toxoplasma gondii (Toxoplasmosis), and Toxocara canis (Toxocariasis). All of these agents are responsible for relevant diseases worldwide. Results: Natural naphthoquinones, such as plumbagin, diospyrin, burmanin, lapachol, lawsone and psychorubrin, show an antiprotozoal activity similar or enhanced antiprotozoal activity to reference drugs. Some naphthoquinones obtained by synthesis or semi-synthesis showed better biological activity or less toxic effects than natural compounds. Conclusion: In this review, natural and synthetic naphthoquinones showed antiparasitic activity, in most cases, with improved results than current drugs currently used in clinical trials. A modification of their structure with different functional groups can enhance their biological effects, improve solubility, and reduce undesirable side effects. Therefore, naphthoquinones are important molecules in the development of new chemotherapeutic agents against parasitic diseases.
dc.format.extent24 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/1568026621666210915121348
dc.identifier.eissn1873-5294
dc.identifier.issn1568-0266
dc.identifier.pubmedidMEDLINE:34525920
dc.identifier.urihttps://doi.org/10.2174/1568026621666210915121348
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102885
dc.identifier.wosidWOS:000745302100004
dc.information.autorucEscuela de Química; Salas Sánchez, Cristián Osvaldo; 0000-0001-7620-2459; 101425
dc.issue.numero22
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2069
dc.pagina.inicio2046
dc.rightsacceso restringido
dc.subjectNaphthoquinones
dc.subjectLeishmania spp
dc.subjectTrypanosoma cruzi
dc.subjectPlasmodium falciparum
dc.subjectToxoplasma gondii
dc.subjectToxocara canis
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.titleNatural and Synthetic Naphthoquinones as Potential Anti-Infective Agents
dc.typeartículo de revisión
dc.volumen21
sipa.codpersvinculados101425
sipa.trazabilidadWOS;18-03-2022
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