EFFECTS OF CAPTOPRIL VERSUS MILRINONE THERAPY IN MODULATING THE ADRENERGIC NERVOUS-SYSTEM RESPONSE TO EXERCISE IN CONGESTIVE HEART-FAILURE

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dc.contributor.authorCORBALAN, R
dc.contributor.authorJALIL, J
dc.contributor.authorCHAMORRO, G
dc.contributor.authorCASANEGRA, P
dc.contributor.authorVALENZUELA, P
dc.date.accessioned2025-01-23T19:23:17Z
dc.date.available2025-01-23T19:23:17Z
dc.date.issued1990
dc.description.abstractThe potential adverse consequences of increased adrenergic nervous system activity in patients with heart failure are now recognized. Modulation of the plasma noradrenaline response to submaximal exercise should be desirable. The long-term (9 weeks) effects of milrinone (10 mg 4 times a day) or captopril (50 mg 3 times a day) compared to placebo were evaluated in a double-blind crossover study, in 16 patients with stable, congestive heart failure receiving digoxin and furosemide. After treatment, clinical status (score range 0 to 14 points) improved significantly with both milrinone (4.4 .+-. 0.5, p < 0.01) and captopril (4.1 .+-. 0.4, p < 0.01). Plasma noradrenaline at rest was similar with both drugs and not significantly different from placebo. During submaximal exercise it increased significantly to 1,295 .+-. 174 pg/ml with milrinone; this response was reduced significantly with captopril, to 820 .+-. 100 pg/ml (p < 0.01). Thus, long-term therapy with both captopril and milrinone improved the clinical score, but only captopril reduced the plasma noradrenaline response to submaximal exercise. These findings suggest that angiotensin-enzyme inhibition with captopril will modulate the adrenergic system response to daily activities in patients with chronic congestive heart failure and therefore could have additional salutary effects beyond vasodilatation.
dc.fuente.origenWOS
dc.identifier.eissn1879-1913
dc.identifier.issn0002-9149
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99189
dc.identifier.wosidWOS:A1990CQ72500018
dc.issue.numero9
dc.language.isoen
dc.pagina.final649
dc.pagina.inicio644
dc.revistaAmerican journal of cardiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECTS OF CAPTOPRIL VERSUS MILRINONE THERAPY IN MODULATING THE ADRENERGIC NERVOUS-SYSTEM RESPONSE TO EXERCISE IN CONGESTIVE HEART-FAILURE
dc.typeartículo
dc.volumen65
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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