CALCIUM PARADOX IN SKELETAL-MUSCLES - PHYSIOLOGICAL AND MICROSCOPIC OBSERVATIONS

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dc.contributor.authorSOZA, M
dc.contributor.authorKARPATI, G
dc.contributor.authorCARPENTER, S
dc.date.accessioned2025-01-23T19:26:35Z
dc.date.available2025-01-23T19:26:35Z
dc.date.issued1986
dc.description.abstractImmersion of rat hemidiaphragms in Ca2+-free Krebs solution (KS) containing Ca2+ chelator in vitro leads to separation of basal lamina from the plasma membrane, as well as transient contracture and rapid loss of twitch response [calcium paradox (CP) phase 1]. Subsequent immersion in regular KS results in necrosis of muscle fibers accompanied by slowly increasing contracture (CP phase 2). This contracture could be presented or reduced by using either Ca2+-free KS or calcium channel blockers, but not by dantrolene sodium, implying that after drastic reduction of extracellular and sarcolemmal Ca2+ during CP phase 1, the sarcolemma has lost its ability to control normal Ca2+ fluxes. Contracture did not develop at 21.degree. C. CP is a convenient model to study calcium-induced muscle cell death and the role of Ca2+ in maintaining sarcolemmal integrity.
dc.fuente.origenWOS
dc.identifier.eissn1097-4598
dc.identifier.issn0148-639X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99630
dc.identifier.wosidWOS:A1986A333900005
dc.issue.numero3
dc.language.isoen
dc.pagina.final232
dc.pagina.inicio222
dc.revistaMuscle & nerve
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCALCIUM PARADOX IN SKELETAL-MUSCLES - PHYSIOLOGICAL AND MICROSCOPIC OBSERVATIONS
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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