MICROTUBULE DENSITY AND SIZE OF AXONS IN EARLY DIABETES - IMPLICATIONS FOR NERVE-CELL HOMEOSTASIS

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dc.contributor.authorITURRIAGA, R
dc.date.accessioned2025-01-23T19:27:04Z
dc.date.available2025-01-23T19:27:04Z
dc.date.issued1985
dc.description.abstractThe density of microtubles and the axonal caliber were studied in myelinated axons from sural nerves of young male alloxan-diabetic and age-matched rats, at 0, 15, 30 and 60 days after diabetes induction. The longitudinal growth of axons was normal in diabetic rats, but, in contrast, the radial growth of axons was impaired. The axonal area was 20% less than normal in diabetic rats at the 60th day. Microtubule density was assessed in 3-.mu.m-diameter axons. No differences in microtubule density (range: 25.0-28.0 mictrotubules/.mu.m2) were found between or within diabetic and control groups. The subnormal axonal size in diabetic rats entailed a reduced content of microtubules in a nerve trunk because the relation between axonal size and mictrotuble density remained normal. Apparently mictrotubule density was independent of axonal length, and of age, weight or diabetic conditions of rats and was related only to the axonal size. These findings have implications in nerve cell homeostatis.
dc.fuente.origenWOS
dc.identifier.eissn1090-2430
dc.identifier.issn0014-4886
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99686
dc.identifier.wosidWOS:A1985AFJ1300013
dc.issue.numero1
dc.language.isoen
dc.pagina.final175
dc.pagina.inicio165
dc.revistaExperimental neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMICROTUBULE DENSITY AND SIZE OF AXONS IN EARLY DIABETES - IMPLICATIONS FOR NERVE-CELL HOMEOSTASIS
dc.typeartículo
dc.volumen88
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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