Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study

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dc.contributor.authorJara-Guajardo, Pedro
dc.contributor.authorMorales-Zavala, Francisco
dc.contributor.authorBolanos, Karen
dc.contributor.authorGiralt, Ernest
dc.contributor.authorAraya, Eyleen
dc.contributor.authorAcosta, Gerardo A.
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorAlvarez, Alejandra R.
dc.contributor.authorKogan, Marcelo J.
dc.date.accessioned2025-01-20T17:19:50Z
dc.date.available2025-01-20T17:19:50Z
dc.date.issued2023
dc.description.abstractIntroduction: The development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by computed tomography (CT) and measured the pharmacokinetic parameters and bioaccumulation of the nanosystem.Methods: The GNRs were functionalized with two peptides, Ang2 and D1, which conferred on them the properties of crossing the blood-brain barrier and binding to amyloid aggregates, respectively, thus making them a diagnostic tool with great potential for AD. The nanosystem was administered intravenously in APPswe/PSEN1dE9 model mice of 4-, 8- and 18-months of age, and the accumulation of gold nanoparticles was observed by computed tomography (CT). The gold accumulation and biodistribution were determined by atomic absorption.Results: Our findings indicated that 18-month-old animals treated with our nanosystem (GNR-D1/Ang2) displayed noticeable differences in CT signals compared to those treated with a control nanosystem (GNR-Ang2). However, no such distinctions were observed in younger animals. This suggests that our nanosystem holds the potential to effectively detect AD pathology.Discussion: These results support the future development of gold nanoparticle-based technology as a more effective and accessible alternative for the diagnosis of AD and represent a significant advance in the development of gold nanoparticle applications in disease diagnosis.
dc.fuente.origenWOS
dc.identifier.doi10.2147/IJN.S435472
dc.identifier.issn1178-2013
dc.identifier.urihttps://doi.org/10.2147/IJN.S435472
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91410
dc.identifier.wosidWOS:001136701200001
dc.language.isoen
dc.pagina.final8185
dc.pagina.inicio8169
dc.revistaInternational journal of nanomedicine
dc.rightsacceso restringido
dc.subjectcomputed tomography
dc.subjectgold nanorods
dc.subjectamyloid-beta
dc.subjectA beta
dc.subjectAlzheimer's disease
dc.subjectdiagnostic
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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