Usefulness of intraoperative parathormone measurement to predict surgical cure in primary hyperparathyroidismUtilidad de la PTH intraoperatoria como predictor de curación quirúrgica en hiperparatiroidismo primario

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dc.contributor.authorDomínguez J.M.
dc.contributor.authorVelasco S.
dc.contributor.authorArteaga E.
dc.contributor.authorCampusano C.
dc.contributor.authorFardella C.
dc.contributor.authorLópez J.M.
dc.contributor.authorMosso L.
dc.contributor.authorRodríguez J.A.
dc.contributor.authorGonzález G.
dc.contributor.authorGoñi I.
dc.contributor.authorLeón A.
dc.contributor.authorGonzález H.
dc.contributor.authorClaure R.
dc.date.accessioned2024-08-15T08:00:12Z
dc.date.available2024-08-15T08:00:12Z
dc.date.issued2009
dc.description.abstractThe aim of the surgical treatment of primary hyperparathyroidism (PHPT) is to achieve its complete cure, evidenced by a normal serum calcium in the postoperative period. Measurement of intraoperative serum parathormone (PTH) can be useful to predict complete cure of the disease. Aim: To assess the usefulness of intraoperative PTH measurement to predict complete cure of PHPT. Material and methods: Serum PTH was measured to all patients operated for PHPT between 2003 and 2008, before and five and ten minutes after the excision of the parathyroid gland causing the disease. The criteria for complete cure were a normal serum calcium at 24 hours and 6 months after surgery and the pathological confirmation of parathyroid gland excision. Results: Eighty eight operated patients, aged 58±15 years (72 females) were studied. Sixty four percent were asymptomatic and their preoperative serum calcium was 11.6±1.2 mg/dl. A normal serum calcium was achieved in 86 patients (98%) at 24 hours and 50 of 52 patients followed for six months (96%). The pathological study disclosed an adenoma in 69 (78%), and multiglandular disease in 16 (18%), a parathyroid cancer in one and a normal gland in one patient. Intraoperative PTH predicted early and definitive cure in 97% and 100% of patients with a single adenoma, respectively. Among patients with multiglandular disease, the predictive figures were 94% and 100%, respectively. Conclusions: Intraoperative PTH measurement efficiently predicts early and definitive surgical cure of PHPT.
dc.format.extent1 página
dc.fuente.origenScopus
dc.identifier.doi10.1210/jc.85.5.1863
dc.identifier.eissn07176163
dc.identifier.issn00349887 07176163
dc.identifier.pubmedid20361135
dc.identifier.scopusidSCOPUS_ID:76749128981
dc.identifier.urihttps://doi.org/10.1210/jc.85.5.1863
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87450
dc.identifier.wosidWOS:000281989401443
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero3
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1596
dc.pagina.inicio1591
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subjectHyperparathyroidism
dc.subjectParathyroid diseases
dc.subjectParathyroid hormone
dc.subjectPrimary
dc.titleUsefulness of intraoperative parathormone measurement to predict surgical cure in primary hyperparathyroidismUtilidad de la PTH intraoperatoria como predictor de curación quirúrgica en hiperparatiroidismo primario
dc.typeartículo
dc.volumen137
sipa.codpersvinculados88201
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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