INDUCTION OF PEROXISOMAL FATTY ACYL-COENZYME A-OXIDASE AND TOTAL CARNITINE ACETYL-COENZYME A-TRANSFERASE IN PRIMARY CULTURES OF RAT HEPATOCYTES BY GARLIC EXTRACTS

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dc.contributor.authorORELLANA, A
dc.contributor.authorKAWADA, ME
dc.contributor.authorMORALES, MN
dc.contributor.authorVARGAS, L
dc.contributor.authorBRONFMAN, M
dc.date.accessioned2025-01-23T19:22:27Z
dc.date.available2025-01-23T19:22:27Z
dc.date.issued1992
dc.description.abstractGarlic has been proposed as a natural hypolipidemic substance. Most hypolipidemic compounds induce peroxisomal proliferation and increase enzyme activities associated with peroxisomal beta-oxidation in rat liver. Here we report that garlic methanol-extracts behave as hypolipidemic drugs, increasing the activity of peroxisomal fatty acyl-coenzyme A oxidase and of total carnitine acetyl-coenzyme A transferase in primary cultures of rat hepatocytes. Both enzymes are considered markers associated with increased peroxisomal beta-oxidation. As in the case of hypolipidemic peroxisome proliferators, garlic extracts partially prevented the decrease in fatty acyl-coenzyme A oxidase as the culture aged. No changes were observed in the activity of microsomal NADPH cytochrome c reductase or of mitochondrial glutamate dehydrogenase.
dc.fuente.origenWOS
dc.identifier.issn0378-4274
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99038
dc.identifier.wosidWOS:A1992HC09300002
dc.issue.numero1
dc.language.isoen
dc.pagina.final17
dc.pagina.inicio11
dc.revistaToxicology letters
dc.rightsacceso restringido
dc.subjectPEROXISOMES
dc.subjectHYPOLIPIDEMIC
dc.subjectGARLIC
dc.subjectHEPATOCYTES
dc.subjectCULTURES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINDUCTION OF PEROXISOMAL FATTY ACYL-COENZYME A-OXIDASE AND TOTAL CARNITINE ACETYL-COENZYME A-TRANSFERASE IN PRIMARY CULTURES OF RAT HEPATOCYTES BY GARLIC EXTRACTS
dc.typeartículo
dc.volumen60
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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