INVOLVEMENT OF POSTJUNCTIONAL PURINERGIC MECHANISMS IN THE FACILITATORY ACTION OF BRADYKININ IN NEUROTRANSMISSION IN THE RAT VAS-DEFERENS

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dc.contributor.authorDONOSO, MV
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:24:12Z
dc.date.available2025-01-23T19:24:12Z
dc.date.issued1989
dc.description.abstractTo investigate the nature of the bradykinin-induced potentiation of electrically driven muscle twitches in the isolated vas deferens, bradykinin, noradrenaline and adenosine 5''-triphosphate (ATP) concentration-response curves were made with control, reserpinized and chemically sympathectomized rats. Bradykinin potentiated the ATP- but not the noradrenaline-induced contractions in the epididymal and prostatic segments of the ductus. The epididymal segment of the ductus did not respond to transmural electrical stimulation following reserpine treatment. Bradykinin potentiated the muscular contractions caused by exogenous ATP but not by noradrenaline. In contrast, the transmurally evoked twitches of the prostatic portion of the ductus remained almost unaltered; bradykinin increased the motor effect of ATP without modifying the potency of noradrenaline. All neuronally induced contractile activity was absent in sympathetomized rats; bradykinin potentiated the contractile effect of ATP without altering the noradrenaline-induced contractions. These results suggest that bradykinin potentiates the ATP-evoked contractions by acting postjunctionally.
dc.fuente.origenWOS
dc.identifier.eissn1879-0712
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99324
dc.identifier.wosidWOS:A1989T219400008
dc.issue.numero2
dc.language.isoen
dc.pagina.final273
dc.pagina.inicio263
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINVOLVEMENT OF POSTJUNCTIONAL PURINERGIC MECHANISMS IN THE FACILITATORY ACTION OF BRADYKININ IN NEUROTRANSMISSION IN THE RAT VAS-DEFERENS
dc.typeartículo
dc.volumen160
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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