PLATELET OF ALZHEIMER PATIENTS - INCREASED COUNTS AND SUBNORMAL UPTAKE AND ACCUMULATION OF [C-14] 5-HYDROXYTRYPTAMINE

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dc.contributor.authorINESTROSA, NC
dc.contributor.authorALARCON, R
dc.contributor.authorARRIAGADA, J
dc.contributor.authorDONOSO, A
dc.contributor.authorALVAREZ, J
dc.date.accessioned2025-01-23T19:21:34Z
dc.date.available2025-01-23T19:21:34Z
dc.date.issued1993
dc.description.abstractPlatelets are the main source of 5-hydroxytryptamine (5-HT) and amyloid precursor protein (APP) found in plasma. We studied a possible correlation between platelet markers and the clinical diagnosis of Alzheimer disease (AD). Our results indicate that in AD patients: (a) platelets are elevated, (b) their ability to accumulate 5-HT decreases and, (c) the kinetic parameters of 5-HT uptake are altered (decreased K-m and V-max), compared to non-demented healthy individuals. An aged Down syndrome patient presents even more deviant alterations. Our finding supports the idea that platelets may provide a systemic marker of AD, and eventually be useful for the clinical diagnosis of the disease.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98804
dc.identifier.wosidWOS:A1993MH36000003
dc.issue.numero1
dc.language.isoen
dc.pagina.final10
dc.pagina.inicio8
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectHUMAN DEMENTIA
dc.subjectPLATELET
dc.subjectSEROTONIN 5-HT UPTAKE
dc.subjectDOWN SYNDROME
dc.subjectALZHEIMER DIAGNOSTIC TEST
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePLATELET OF ALZHEIMER PATIENTS - INCREASED COUNTS AND SUBNORMAL UPTAKE AND ACCUMULATION OF [C-14] 5-HYDROXYTRYPTAMINE
dc.typeartículo
dc.volumen163
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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