CHANGES IN CONNEXIN43, THE GAP JUNCTION PROTEIN OF ASTROCYTES, DURING DEVELOPMENT OF THE RAT PINEAL-GLAND

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dc.contributor.authorBERTHOUD, VM
dc.contributor.authorSAEZ, JC
dc.date.accessioned2025-01-23T19:21:51Z
dc.date.available2025-01-23T19:21:51Z
dc.date.issued1993
dc.description.abstractThe abundance of gap junctions between rat pineal astrocytes formed by connexin43 (Cx43) was studied during development. Levels and distribution of Cx43 were measured by immunoblotting and indirect immunofluorescence, respectively. The amount of Cx43 in cells located within the gland was low until about the 7th postnatal day and increased to adult values between the 14th and 21 st days postpartum. Although astrocytes, recognized by their vimentin immunoreactivity, were scarce before birth, they were abundant by the 7th postnatal day suggesting that the low levels of Cx43 found at this age corresponded to a low expression of this protein. Localization of the immunoreactivity to Cx43 and vimentin showed a close correlation, indicating that mature or immature pineal astrocytes form -ap junctions made of Cx43. Since Cx43 levels attained their adult values at about the time the innervation and the functional state of the gland reached maturity weeks after birth), it is proposed that astrocyte gap functions are involved in the function of the adult rat pineal gland.
dc.description.funderNIDDK NIH HHS
dc.fuente.origenWOS
dc.identifier.eissn1600-079X
dc.identifier.issn0742-3098
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98889
dc.identifier.wosidWOS:A1993LC75200003
dc.issue.numero2
dc.language.isoen
dc.pagina.final72
dc.pagina.inicio67
dc.revistaJournal of pineal research
dc.rightsacceso restringido
dc.subjectINTERCELLULAR COMMUNICATION
dc.subjectCONNEXIN
dc.subjectGLIA
dc.subjectINTERSTITIAL CELL
dc.subjectVIMENTIN
dc.subjectONTOGENY
dc.subjectEPIPHYSIS CEREBRI
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCHANGES IN CONNEXIN43, THE GAP JUNCTION PROTEIN OF ASTROCYTES, DURING DEVELOPMENT OF THE RAT PINEAL-GLAND
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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